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Predictors and Rate of Anticoagulant Therapy Discontinuation in Patients with Atrial Fibrillation

25. 5. 2023 Source: Anticoagulant Treatment

With the worldwide increase in the prevalence of atrial fibrillation (AF), the use of anticoagulants (warfarin, DOACs –⁠ direct oral anticoagulants) to reduce the risk of ischemic stroke (iCMP) is also rising. However, continuous use is essential. An Australian study analyzed available national data to investigate the rate of therapy discontinuation for individual anticoagulants and the predictors of persistence on treatment.

Association Between Sartan Therapy and Lower Incidence of Epilepsy in Hypertensive Patients?

Arterial hypertension (AH) is one of the non-cerebral comorbidities of epilepsy, with the renin-angiotensin system possibly being the central mediator of the connection between these diseases. The…

25. 5. 2023 Source: Sartans in the Treatment of Hypertension

RETRO-TAS Study –⁠ Trifluridine/Tipiracil in Pretreated mCRC in Real-World Practice

How does trifluridine/tipiracil (FTD/TPI), which demonstrated efficacy in clinical trials in chemotherapy-refractory metastatic colorectal cancer (mCRC), fare in real-world practice? This was…

25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas

Study TACTIC –⁠ Efficacy and Safety of Trifluridine/Tipiracil in Pre-treated mCRC Patients in Real-world Practice

In the pivotal phase III RECOURSE randomized placebo-controlled study, therapy with trifluridine/tipiracil (FTD/TPI) was associated with improved overall survival and progression-free survival in…

25. 5. 2023 Source: Treatment of Gastrointestinal Carcinomas

Sotorasib in the Treatment of a Patient with NSCLC and DIC –⁠ A Case Report

Sotorasib is the first clinically used inhibitor of the KRAS oncogene with the G12C mutation. Its efficacy in the targeted treatment of non-small cell lung cancer (NSCLC) is still under research, but…

24. 5. 2023 Source: Lung Cancer

Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene

Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below…

24. 5. 2023 Source: Lung Cancer

“Customized Schizophrenia Treatment”: Benefits of Therapeutic Innovations in Inpatient and Outpatient Care Thanks to Gentler Antipsychotics

In the field of schizophrenia treatment, the possibility of significantly greater individualization, brought about by gentler antipsychotics, is currently a hot topic. A major focus is the…

24. 5. 2023 Source: Modern Treatment of Schizophrenia

Angiodysplasia as a Serious Problem in Patients with von Willebrand Disease −⁠ Case Study

Bleeding into the gastrointestinal tract can become a very significant cause of morbidity and mortality in patients with von Willebrand disease (vWD). It has been described that gastrointestinal (GI)...

19. 5. 2023 Source: Von Willebrand Disease

Pharmacotherapy of Glaucoma in a Nutshell According to the Latest Recommendations of the European Glaucoma Society

The European Glaucoma Society published its latest, 5th version of recommendations for the treatment of glaucoma in 2021. The following text, based on these recommendations, focuses in a nutshell on the...

18. 5. 2023 Source: Treatment of Glaucoma

Model of Risk of Bleeding Associated with Physical Activity in Hemophiliacs with Factor and Non-Factor Treatment

In the treatment of hemophilia A, both FVIII concentrate replacement therapy and non-factor therapy are available today. However, there is no clinical data comparing the risk of bleeding associated…

18. 5. 2023 Source: Hemophilia

When to Consider Gaucher Disease and How to Diagnose It Early and Correctly

Considering Gaucher disease (GD) as a cause of a patient's problems, especially in the case of splenomegaly and bleeding manifestations, is very important, regardless of age. Screening using the dry…

16. 5. 2023 Source: Rare Diseases in Hematology

COMMENTARY FROM PRACTICE: On Some Aspects of Care for Patients with Parkinson's Disease

What issues do we still encounter in the diagnosis and treatment of Parkinson's disease even today, despite medical advancements? How to fine-tune the management of care for these patients, facilitate...

15. 5. 2023 Source: Parkinson's Disease

Detection of ceftazidime/avibactam-resistant Enterobacteriaceae strains using a new rapid test

Ceftazidime/avibactam (CZA) is a relatively new antibiotic with very good efficacy against carbapenem-resistant Enterobacteriaceae. Unfortunately, strains resistant to this antimicrobial treatment…

15. 5. 2023 Source: Anti-Infectives

Diagnosing Myelodysplastic Syndrome According to MDS Europe

In 2021, the European Hematology Association (EHA) endorsed the recommendations of the MDS Europe group for the diagnosis of myelodysplastic syndrome (MDS). MDS-RIGHT is a large European project…

15. 5. 2023 Source: proLékaře.cz

Proton Therapy and Its Results in the Treatment of Bilateral Breast Cancer

Breast cancer is the most common malignant tumor disease in women, and its incidence sharply increases after the age of 50. Although its incidence shows a continuously increasing trend, the…

11. 5. 2023 Source: Proton Radiotherapy

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