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News Practical Experiences Using ZULP in Cardiology
The application of a product containing ferric carboxymaltose (FCM) or the use of a contrast agent with sulfur hexafluoride in microbubbles are examples of the use of specially accounted medicinal products (ZULP) in cardiology practice. "A benefit for the patient is that they receive the indicated preparation directly in the office and do not have to procure it themselves from a pharmacy," says Dr. Jiří Veselý, head physician of the Edumed cardiology clinic in Jaroměř, with whom we discussed the advantages and disadvantages of using ZULP and his experiences with this system.
News Wound Healing and Exudate – A Comprehensive Look at Moisture Management in Wounds
Exudate produced during the inflammatory phase of healing is a crucial factor that ensures a moist environment in the wound, provides nutrients for cellular metabolism, and supports autolytic debridement. Without proper exudate management and maintenance of optimal moisture in the wound, patients are exposed to a range of risks and complications in healing.
News How Do Patients Themselves Perceive Today's Treatment Options for ITP and What Are Their Biggest Fears?
What is the perception and view of the treatment options for immune thrombocytopenia (ITP) from the patients' perspective, what do they fear, what approaches do they prefer, and why? Lozano et al. included a discussion on this topic in their review article for Expert Review of Hematology, which can be helpful in clinical practice for better understanding patients' needs and adjusting treatment algorithms.
News Anticoagulants and Antiplatelets in the Treatment of Acute Coronary Syndromes
Anticoagulants and antiplatelets are a key part of the therapeutic strategies used in the treatment of acute coronary syndromes (ACS). They reduce the risk of acute and late complications, morbidity, and mortality in patients. On the other hand, their main disadvantage is the potential occurrence of bleeding complications. Therefore, the goal of physicians is to use these medications appropriately, maximizing benefits for patients while minimizing the risk of bleeding.
News Impact of Antiemetic Prophylaxis on Quality of Life of Patients Treated with Chemotherapy – Data from Practice
Chemotherapy-induced nausea and vomiting (CINV) is a relatively common complication of cancer treatment with a significantly negative impact on patients' quality of life. A large prospective analysis of real-world clinical practice data was conducted in Germany, examining the efficacy and safety of treatment with the oral combination of netupitant and palonosetron and the impact of this therapy on patients' quality of life.
News Hybrid Cooperative Complexes in the Treatment of Osteoarthritis
Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the related choice of appropriate intra-articular viscosupplementation, with emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.
News Does Beta-Blocker Therapy Reduce the Cardiovascular Benefit of Aerobic Exercise in Patients with Arterial Hypertension?
Regular aerobic exercise is generally recommended for patients suffering from arterial hypertension to reduce blood pressure values, improve physical fitness, and other parameters. The intensity of exercise is most often derived from the target heart rate, which is pharmacologically influenced in patients on beta-blockers. The question, therefore, is whether aerobic exercise brings the same cardiovascular benefit to this group of patients as it does to those not taking beta-blockers.
News Impact of ACEi and ARBs on Lung Function in Patients with Hypertension
Worsening respiratory functions can significantly influence the choice of antihypertensive medication. A recently published study explored whether angiotensin-converting enzyme inhibitors (ACEi) can worsen lung function and whether this effect also appears with angiotensin II receptor blockers (ARBs, i.e., sartans). These findings are crucial for clinical practice, especially in treating patients at high risk for respiratory adverse effects.
News ITP from the Patients' Perspective: How It Affects Their Lives and Which Needs They Find Unmet?
In recent years, new therapeutic options for immune thrombocytopenia (ITP) have been introduced, which are effective for many patients and have significantly improved their quality of life. However, it remains crucial to listen to patients' experiences with treatment and any unmet needs they may have. A meeting of the Platelet Disorder Support Association brought forth many interesting findings and shared experiences. So what troubles ITP patients the most?
News Low-Molecular-Weight Heparins in Thromboprophylaxis After Major Orthopedic and Traumatological Procedures According to Current Recommendations
Patients after major orthopedic and traumatological procedures are at high risk of thromboembolic disease. This is especially true for people undergoing hip and knee replacement or patients with a proximal femur fracture and severe lower limb injury. The routine implementation of pharmacological thromboprophylaxis, such as low-molecular-weight heparins, is currently the gold standard in perioperative care in these cases.
News Spasmolytic Effect of Metamizole
A study aimed at clarifying the mechanism of action of metamizole suggested that the clinically proven effect of this analgesic on colicky pain originating from the biliary tract could be due to agonism on β2-adrenergic receptors in the smooth muscle of the bile ducts.
News When You Say Amyloid…
The term 'amyloid' was first used by the German doctor Rudolf Virchow in the mid-19th century. He described it as a pathological substance which he originally thought was starch. Although it was quickly discovered that it was a substance of protein nature, the reference to starch (from the Greek amylon) remained in the name.
News Valproate and Lithium in Maintenance Therapy of Bipolar Affective Disorder
Among the so-called mood stabilizers, drugs commonly used in the therapy of bipolar affective disorder, are valproate and lithium. Canadian authors recently conducted a post hoc analysis of a study aimed at comparing their effectiveness in the maintenance treatment of bipolar I disorder.
News How Does Artificial Intelligence Help in Drug Development?
In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer the development of new drugs?
News How to Detect COPD Early in Primary Care?
Chronic obstructive pulmonary disease (COPD) can be present even in individuals without obvious subjective symptoms, or the emerging symptoms may be overlooked by both the patient and the doctor due to their very gradual development. So, what is the path to early detection of COPD in primary care, and how can this disease be distinguished from others accompanied by similar manifestations?
News Anticoagulation Therapy in Patients on ECMO During the COVID-19 Pandemic
In the past 2 years, the use of extracorporeal membrane oxygenation (ECMO) in intensive care units (ICU) has increased in connection with the treatment of severe COVID-19 pneumonia. Dr. Pilar Marcos Neira from the ICU at Germans Trias i Pujol Hospital in Barcelona has compiled a summary of updated knowledge on anticoagulation therapy in these patients.
News How Does Memantine Currently Stand in Alzheimer's Disease and Other Dementias
A comprehensive meta-analysis from 2019 examined the effect and safety of administering memantine, particularly in patients with moderate to severe Alzheimer's disease. How did memantine fare?
News Absorption of Levothyroxine: What Has the New Formulation of LT4-Containing Medicinal Products Brought?
Lifelong use of levothyroxine (LT4) is the cornerstone of hypothyroidism treatment. The narrow therapeutic range of LT4 places increased emphasis on accurate dosing and appropriate titration, making the introduction of new LT4 formulations with more precise active ingredient dosing and higher levels of bioequivalence a pathway to facilitate LT4 titration and improve patient adherence.
News Effectiveness of Bisoprolol in Patients with Cardiac Arrhythmias – A Systematic Review of Studies
Last year, a Franco-Romanian team published a study that conducted a systematic review of existing evidence on bisoprolol in the context of arrhythmia treatment. The authors noted that bisoprolol, like other beta-blockers (BB), is used for a variety of cardiovascular diseases, but it is not mentioned in the European Society of Cardiology (ESC) guidelines for managing patients with ventricular arrhythmias and preventing sudden cardiac death.