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News New Drug in the Biologic Therapy Arsenal for Plaque Psoriasis
Bimekizumab shows promising effects in clinical studies with psoriasis patients. Let's take a closer look at this recently approved drug in our brief summary.
News Three times on the topic of therapeutic cannabis usage possibilities – case studies from Czech practice
The following case studies from real Czech practice describe three cases of patients with various diagnoses, indicated for cannabis extract administration. In the first case, there was significant pain relief in an elderly patient with vertebrogenic pain syndrome. The second case study outlines the possibilities of using cannabis extract in the treatment of neuropathic pain in a polymorbid elderly patient. The final contribution describes the effect of this preparation in palliative therapy of an oncological patient.
News Proton Therapy and Its Results in the Treatment of Bilateral Breast Cancer
Breast cancer is the most common malignant tumor disease in women, and its incidence sharply increases after the age of 50. Although its incidence shows a continuously increasing trend, the development of mortality is more favorable. Thanks to nationwide screening and more successful therapy, mortality has long been stable, even slightly decreasing. A relatively rare variant of this oncological disease is primary synchronously detected bilateral breast cancer (PSBBC). Experts from the Proton Therapy Center in Prague are focusing on the use of proton radiotherapy in the treatment of this clinical entity.
News How Does Empagliflozin Stand in Terms of Diabetic Retinopathy Risk? We Have Answers Not Only from Controlled Studies but Also from Real Practice
Modern antidiabetics – gliflozins and glucagon-like peptide-1 receptor agonists (GLP-1RA) – significantly help improve the management of type 2 diabetes (DM2). In addition to reliable glycemic control, they offer other benefits. For example, gliflozins are known for their cardio- and renoprotective properties. GLP-1RA also reduce cardiovascular (CV) risk, though clinical evaluation (SUSTAIN-6) suggests a possible higher risk of retinopathy. This is also being investigated with gliflozins. How empagliflozin fares in this respect has been shown by the prospective randomized EMPA-REG OUTCOME study and the real-world EMPRISE evaluation.
News Trifluridine/Tipiracil in the 3rd Line Treatment of mCRC − Case Study
The following case study describes the treatment of a patient with metastatic colorectal cancer (mCRC) and the benefits of trifluridine/tipiracil within the therapeutic algorithm.
News Echocardiography in the Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?
News Height as an Independent Risk Factor for Varicose Veins
Authors of a study published in the journal Circulation analyzing data from nearly half a million people found another risk factor for the development of varicose veins – a person's height. They further assessed the possible causal role in the development of this pathology.
News Correct Selection of Appropriate Incontinence Aid is Crucial for Addressing Patient's Difficulties
Urinary incontinence is an uncomfortable issue that can be resolved by choosing the right incontinence aids. Selecting a quality product is most important for the patient − it affects their comfort and mental well-being, but choosing the right aid can also be complicated for doctors. The market offers many products of different brands and qualities, where the absorption capacity is often the main selection criteria. However, other important aspects must also be considered.
News Chemotherapy as a Risk Factor for Severe COVID-19 Course?
During the coronavirus pandemic, patients with malignant neoplastic diseases are considered an at-risk group. Whether chemotherapy is a risk factor for a more severe course of COVID-19 was the subject of the study presented below.
News What is the significance of hormones in the pathophysiology of migraine?
Migraine is a complex neurovascular disease characterized by the dysfunction of the nociceptive trigeminovascular system in its pathophysiology. Its prevalence is 2-3 times higher in women than in men. The cause of this difference has not yet been fully elucidated, but it appears that the fluctuation of ovarian hormone levels and its influence on CGRP plays an important role. The following article summarizes findings on the hormonal influence of migraine and also discusses new prophylactic drugs – anti-CGRP antibodies.
News Prevention of Skeletal Events in the Therapy of Patients with Advanced Prostate Cancer
Prostate cancer most commonly forms metastases in the bones. In patients with this advanced disease, skeletal events occur, negatively affecting their quality of life. Zoledronic acid and denosumab are used to prevent their occurrence, and their results in this indication were evaluated and compared in the cited study below.
News IEC 2023: Key Challenges for Epilepsy Patients Include Status Epilepticus and Anxiety Management
Why is anxiety a significant issue for epilepsy patients? What do current insights say about the connection between epilepsy and anxiety? Can artificial intelligence be used to predict status epilepticus (SE)? And what is known about the development of late epilepsy following new SE? These and other topics were discussed in September 2023 in Dublin during the 35th International Epilepsy Congress (IEC 2023).
News Desirable Side Effects of Antidiabetics
The days when diabetology was a field solely focused on normalizing blood sugar levels are long gone. Today, the approach in diabetology increasingly prioritizes influencing the patient's overall life prognosis, particularly reducing cardiovascular risk. What can be the desirable side effects of the main groups of antidiabetics that are not related to merely lowering glucose levels?
News To Vaccinate or Not to Vaccinate? That’s the Question for MS and COVID-19
What is the response of patients with multiple sclerosis (MS) to vaccination against COVID-19 considering the type of their treatment? Is there an increased risk of relapse after vaccination? And how to proceed with a particular patient? Although COVID-19 has been a relevant issue for a relatively long time, unfortunately, this topic remains current. Unlike in 2020, however, our knowledge has significantly advanced. Currently, relatively extensive data are available even for specific groups of the population – including precisely MS patients.
News Cell-Based Implant as a Stable System for Biological Therapy Delivery
A team of scientists from Washington University in St. Louis focused on the possibility of delivering biological inhibitors for the treatment of rheumatoid arthritis using modified induced pluripotent stem cells. To verify the effectiveness of the therapy, they used a mouse model of rheumatoid arthritis, and their results represent progress in the development of rheumatoid arthritis treatment.
News Early Detection of Erectile Dysfunction in Men with Type 2 Diabetes
A retrospective study published last year identified predictors of erectile dysfunction in men with type 2 diabetes. The authors recommend screening patients with elevated uric acid levels, diabetes duration ≥ 49 months, and diabetic retinopathy.
News Effectiveness of Arginine in Tooth Cleaning Proven (Not Only) by Quantitative Light-Induced Fluorescence
There is no doubt about the benefits of toothpaste in daily dental care. Today, there are numerous studies proving that brushing without toothpaste does not have the same effectiveness as brushing with toothpaste. It is more effective and, thanks to active ingredients, can slow down or even reverse the development of tooth decay.
News Administration of Low-Molecular-Weight Heparin After Hemorrhagic Stroke: What Is the Appropriate Timing?
Hemorrhagic stroke (HS) is a condition that raises doubts and concerns about anticoagulation. Is early prevention of thromboembolic complications appropriate?
News Meta-analysis of Incidence of Infusion Reactions to Anti-EGFR Antibodies in Patients with mCRC
The application of antibodies against the epidermal growth factor receptor (EGFR), administered in slow infusions mainly as part of the treatment for metastatic colorectal cancer (mCRC), may be accompanied by infusion reactions or hypersensitivity reactions.
News Critical Overview of Clinical Studies on EHL FVIII Preparations
An international team of experts recently published a comprehensive work evaluating the methodology used in clinical trials of various extended half-life (EHL) factor VIII (FVIII) products. Their work does not directly compare the individual products but aims to assess the results of key registration clinical trials from the perspective of the hematologist and everyday clinical practice.
News INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy – Current Guidelines
What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure for monitoring patients and their at-risk relatives? The comprehensive infographic summarizes the current recommendations of American professional societies.
News Quantitative CT as a New Tool for Evaluating COPD in Alpha-1 Antitrypsin Deficiency
For such a rare hereditary disorder as alpha-1 antitrypsin deficiency (AATD), we have so far used functional tests as the main tool for monitoring the progression of lung disease. Now we are moving further. Quantitative CT examination is even more advantageous in terms of assessing clinical development.
News ESC 2022: Can Modern Treatment of Acute Heart Failure Improve (Re)hospitalization Prevention?
Heart failure (HF) and the possibilities of its therapy were one of the frequently discussed topics at this year's annual congress of the European Society of Cardiology (ESC 2022), which took place at the end of August in Barcelona. The potential of current approaches in reducing the risk of hospitalization or rehospitalization due to HF was also discussed. In summary, we present the insights from a symposium focused directly on this issue.
News Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?
Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH). What are its outcomes and in what percentage of cases does it lead to complete cure? A meta-analysis, significantly contributed to by Czech experts, was dedicated to the improvement of signs and symptoms of CTEPH after performing endarterectomy.