Pharmacogenetics of oral antidiabetic treatment

Czech version

Authors: Ivan Tkáč
Authors‘ workplace: IV. interná klinika LF UPJŠ LF a UN L. Pasteura, Košice, Slovenská republika
Published in: Vnitř Lék 2016; 62(3): 186-188
Category: Reviews

Overview

Pharmacogenetics is the study of how genes (individual genotypes) affect a person‘s response to drugs. At present, recommendations made about the treatment of some monogenic forms of diabetes are based on genetic diagnostics. The first studies in the field of pharmacogenetics of oral antidiabetics have now been published which have identified associations of individual genetic variants with response to treatment. The response to sulfonylurea derivatives was significantly associated with the variants KCNJ11/ABCC8, TCF7L2 and CYP2C9. The response to metformin treatment was associated with the genetic variants ATM and SLC47A1. The response to treatment with glitazones was associated with the genetic variant PPARG. The therapeutic response to the treatment with gliptins was associated with the genetic variants TCF7L2 and CTRB1/2. It may be expected that in the near future pharmacogenetic knowledge will also be used within personalized treatment of type 2 diabetes.

Key words:
type 2 diabetes mellitus – pharmacogenetics – monogenic diabetes – oral antidiabetics – personalized treatment

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