Obesity paradoxes

Czech version

Authors: Hana Rosolová
Authors‘ workplace: Centrum preventivní kardiologie II. interní kliniky LF UK a FN Plzeň
Published in: Vnitř Lék 2016; 62(3): 181-182
Category: Reviews

Overview

Obesity (esp. abdominal type) was still considered as a risk factor for cardiovascular disease. During the last decade has a new phenomenon appeared: „obesity paradox“, i.e. patients with high BMI die less frequently than patients with low BMI. Obesity paradox was described first in patients with chronic renal failure, heart failure or in oncological patients, later on in patients with cardiovascular disease and now also in patients with type 2 diabetes. In comparison with population studies, BMI associated with low cardiovascular mortality in patients with Type 2 diabetes is shifted to the higher level than in subjects from general population. Mechanisms of obesity paradox is not yet clarified.

Key words:
cardiovascular mortality – obesity paradox – type 2 diabetes mellitus

Sources

1. Rosolová H, Čech J, Šimon J et al. Short to long term mortality of patients hospitalised with heart failure in the Czech Republic – a report from the Euro Heart Failure Survey. Eur J Heart Fail 2005; 7(5): 780–783.

2. Wohlfahrt P, Lopez-Jimenez F, Krajcoviechova A et al. The Obesity Paradox and Survivors of Ischemic Stroke. J Stroke Cerebrovasc Dis 2015; 24(6):1443–1450.

3. Logue J, Walker JJ, Leese G et al. Association between BMI measured within a year after diagnosis of type 2 diabetes and mortality. Diabetes Care 2013; 36(4): 887–893.

4. The Look AHEAD Research Group. Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes. N Engl J Med 2013; 369(2): 145–154. Erratum in N Engl J Med 2014; 370(19): 1866.

5. Zhao W, Katzmarzyk PT, Horswell R et al. Body Mass Index and the Risk of All-Cause Mortality in Patients with Type 2 Diabetes. Circulation 2014; 130(24): 2143–2151.

6. Must A, Spadamo J, Coakley EH et al. The disease burden associated with overweight and obesity. JAMA 1992; 282(16): 1523–1529.