XIGDUO – fixed combination of the active ingredients dapagliflozin and metformin

Czech version

Authors: Tomáš Edelsberger
Authors‘ workplace: Diabetologická ambulance Krnov
Published in: Vnitř Lék 2016; 62(3): 199-201
Category: Reviews

Overview

Fixed dose combination of two different drugs in the same or related indications are successfully used in various medical fields including diabetology. This article deals with the combination therapy comprising metformin and dapagliflozin in a single preparation, molecules affecting different pathophysiological mechanisms of type 2 diabetes, particularly insulin resistance and increased glucose reabsorption in the kidney. Most patients with type 2 diabetes does not achieve target glycemic control when treated with single antidiabetics and need for proper control of diabetes combination of several different drugs. Using the fixed combination leads to improved patient’s adherence and utilization of the full therapeutic potential of selected drugs.

Key words:
combination therapy – diabetes mellitus – fixed-dose combinations – oral antidiabetics – SGLT2 inhibitors

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