Sodium Hyaluronate and an Iodine Complex - Hyiodine® - New Method of Diabetic Defects Treatment

Czech version

Authors: L. Sobotka ¹; V. Velebný ²; A. Šmahelová ¹; M. Kusalová ¹
Authors‘ workplace: Klinika gerontologická a metabolická Lékařské fakulty UK a FN, Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc. ¹; Contipro, a. s., Dolní Dobrouč, ředitel RNDr. Vladimír Velebný ²
Published in: Vnitř Lék 2006; 52(5): 417-422
Category: Diabetes and other subjects (infection, dermatovenerology and rheumatology) Hradec Králové 3 to 4 June 2005

Overview

Complicated diabetic defects are difficult to heal and frequently result in leg amputation. We have developed a new and unique system for wound treatment, which is based on combination of high molecular weight sodium hyaluronate with an iodine complex - Hyiodine^®. The aim of our study was to assess the effect of this new method of wound dressing on infected diabetic defects healing.

Methods:
The effect of Hyiodine^® was studied on 22 patients suffering from complicated foot diabetic wounds. Hyiodine^® was either spread directly over the wound, or (more frequently) gauze was immersed in Hyiodine^® and then put on/into the wound. Then several layers of dry gauze covered the wound.

Results:
Within 2 - 6 weeks after the onset of treatment all but two defects were filled with granulation tissue. Complete healing was evident in 18 patients within 6 - 20 weeks after the start of treatment, depending on the wound character, localization and extent. Two patients are still treated by Hyiodine^®, and significant improvement is apparent on their wound. Treatment was not successful in two subjects with ischemic defects due to simultaneous arterial occlusion.

Conclusions:
We can conclude that the hyaluronan-iodine complex Hyiodine^® is efficient method for treatment of difficult to heal diabetic defects without complete arterial occlusion.

Key words:
wound healing - diabetes mellitus - diabetic ulcer - hyaluronan - iodine - Hyiodine^®

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