Effects of insulin on glucose metabolism in sepsis

Czech version

Authors: Z. Rušavý; S. Lacigová; Z. Jankovec; M. Žourek; M. Krčma
Authors‘ workplace: Diabetologické a nutriční centrum, I. interní klinika Lékařské fakulty UK a FN, Plzeň, přednosta prof. MUDr. Karel Opatrný, jr., DrSc.
Published in: Vnitř Lék 2006; 52(5): 429-432
Category: Diabetes and other subjects (infection, dermatovenerology and rheumatology) Hradec Králové 3 to 4 June 2005

Overview

The study surveys potential effects of hyperglycemia on prognosis, complications and mortality of critical patients. Normalization of glycemia seems to be an effective therapeutic approach that influences morbidity and mortality of critical patients. Although insulin therapy has many positive effects, it is rather a way how to achieve normoglycemia. Authors present their own research of the impact of plasmatic insulin levels on glucose metabolism. It seems that the ability of critical patients to utilise and store glucose is significantly decreased due to their insulin resistance. Glucose oxidation is decreased only slightly. Glucose utilisation and oxidation in sepsis can be enhanced by administration of insulin.

Key words:
sepsis – insulin clamp – indirect calorimetry – glycaemia – diabetes mellitus – insulin

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