Pathogenesis of the connective tissue in diabetes

Czech version

Authors: J. Škrha
Authors‘ workplace: III. interní klinika 1. lékařské fakulty UK a VFN, Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
Published in: Vnitř Lék 2006; 52(5): 446-450
Category: Diabetes and other subjects (infection, dermatovenerology and rheumatology) Hradec Králové 3 to 4 June 2005

Overview

Non-enzymatic glycation and oxidative stress are main contributors in pathogenesis of the connective tissue changes in diabetes. Properties of separate parts in the connective tissue and particularly those of intercellular matrix may be impaired by both mechanisms. In addition, changes in microcirculation including endothelial dysfunction and also diabetic neuropathy further aggravate tissue impairment. Despite known pathogenic mechanisms in development of diabetic microangiopathy there are series of unresolved questions in the pathogenesis of diabetic skin disorders.

Key words:
diabetes mellitus - connective tissue - protein glycation - oxidative stress

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