Treatment of complicated Crohn’s disease with vedolizumab

Czech version

Authors: B. Pipek ¹; P. Falt ^1–3
Authors‘ workplace: Centrum péče o zažívací trakt, Vítkovická nemocnice, a. s., Ostrava ¹; LF OU v Ostravě ²; Katedra interních oborů, LF UK v Hradci Králové ³
Published in: Gastroent Hepatol 2018; 72(2): 143-147
Category: IBD: Case Report
doi: https://doi.org/10.14735/amgh2018csgh.info02

Overview

Crohn‘s disease is a chronic inflammatory disease of the digestive tract with an unclear etiology and severe exacerbations and complications in many patients. Vedolizumab is a monoclonal antibody against α4β7integrin receptors on the surface of activated leukocytes and is a relatively new biological treatment available in the Czech Republic since 2016. It has high selectivity for the gastrointestinal tract and prevents lymphocytes from moving from the capillary system into the gastrointestinal tract with a relatively low incidence of side effects. It is indicated for the treatment of adult patients with moderate to severe active Crohn’s disease and ulcerative colitis, who either do not tolerate or have inadequately responded or failed to respond to conventional therapy, such as anti-TNF therapy. We present a case report of a patient with a severe and complicated form of Crohn’s disease, in whom conventional treatments, such as steroid and anti-TNF therapy and surgical resection, failed, and who is now being successfully treated with vedolizumab. The patient’s clinical condition improved after vedolizumab treatment and corticosteroid therapy has stopped. Currently, the patient has been on vedolizumab for 1 year and shows deep remission of the disease.

Key words:
Crohn’s disease – vedolizumab – ileocecal resection – endoscopic stricture dilatation – biodegradable stent

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
9. 8. 2017

Accepted:
27. 9. 2017

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