Gastrointestinal symptomatology of familial Mediterranean fever – is this a problem also in Central Europe?

Czech version

Authors: Z. Havlíčeková ¹; M. Jeseňák ¹; N. Mišovicová ²; J. Kršiaková ²; Ľ. Jakušová ¹; Peter Bánovčin ¹
Authors‘ workplace: Centrum pre periodické horúčky, Klinika detí a dorastu JLF UK a UN Martin ¹; Oddelenie lekárskej genetiky, UN Martin ²
Published in: Gastroent Hepatol 2018; 72(2): 152-157
Category: Clinical and Experimental Gastroenterology: Case Report
doi: https://doi.org/10.14735/amgh2018csgh.info04

Overview

Human autoinflammatory diseases are a group of rare, genetically-determined diseases characterized by hyperactivation of innate immune mechanisms in the absence of infectious or autoimmune disease. Familial Mediterranean fever is the most common monogenic autoinflammatory disease, especially among ethnic groups living in the Mediterranean region. The occurrence in other ethnic groups is relatively rare, but due to the migration of populations from Mediterranean regions, it also occurs in Central Europe. In addition to fever, abdominal pain is the most common clinical symptom. The authors present the case reports of four pediatric patients with gastrointestinal symptomatology treated at the Centre for Diagnosis and Treatment of Primary Immunodeficiency at Martin University Hospital, among whom only one had an ancestor in the Mediterranean region.

Key words:
periodic fever – familial Mediterranean fever – abdominal pain – children

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
14. 9. 2017

Accepted:
25. 11. 2017

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