Effect of nitroglycerin on high resolution manometry parameters in patients with achalasia

Czech version

Authors: Peter Bánovčin; Martin Ďuriček; Peter Lipták; R. Hyrdel
Authors‘ workplace: Interná klinika gastroenterologická JLF UK a UN Martin, Slovenská republika
Published in: Gastroent Hepatol 2017; 71(4): 287-292
Category: Clinical and Experimental Gastroenterology: Original Article
doi: https://doi.org/10.14735/amgh2017287

Overview

Nitroglycerin has long been used to relieve symptoms in patients with achalasia. It is well known that nitroglycerin decreases the pressure of the lower esophageal sphincter via mechanisms involving the production of nitric oxide. High resolution manometry (HRM) with esophageal pressure topography provides a more robust and sensitive evaluation of esophageal function, which allows better quantification. However, the effects of nitroglycerin on esophageal function have not yet been quantified using HRM. For example, the effects of nitroglycerin on upper esophageal sphincter in patients with achalasia have not been defined.

Aims and Methods:
The aim of the study was to quantify the effect of nitroglycerin on selected HRM parameters in patients with achalasia. We performed HRM in 15 consecutive patients with achalasia. We quantified the effects of nitroglycerine on esophageal function in patients with achalasia by using HRM measurements according to Chicago criteria. HRM analysis revealed that in patients with achalasia nitroglycerin affects not only the lower esophageal sphincter, but also influences the function of the upper esophageal sphincter. Nitroglycerin challenge may be a useful tool for future motility studies in patients with achalasia.

Key words:
achalasia – nitroglycerin – high resolution manometry – esophagus

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE „uniform requirements“ for biomedical papers.

Submitted:
12.6.2017

Accepted:
8.7.2017

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