The patient with type 2 diabetes is hemodynamically and metabolically stable, despite treatment, the progression of chronic kidney disease proceeds. What other options do we have? A case report

Czech version

Authors: Zbynek Schroner
Authors‘ workplace: Lekárska fakulta, Univerzita Pavla Jozefa Šafárika v Košiciach
Published in: Diab Obez 2023; 23(45): 43-48
Category: Case studies

Overview

The case report describes a patient, which is hemodynamically and metabolically stable, despite treatment, the progression of CKD proceeds. Blocking of increased the mineralocorticoid receptor (MR) by selective, nonsteroidal MR antagonist – finerenone can slow down the progression of CKD, mediating by inflammation and fibrotic mechanisms, which current therapies do not solve, and by that, we can influence the third factor of progression of CKD and type 2 diabetes mellitus (T2DM). From 1st April 2023 in Slovakia finerenone reimbursed therapy is indicated to adult patients for the treatment of CKD with eGFR ≥ 25-< 60 ml/min/1,73 m² (≥ 0,42–< 1 ml/s/1,73 m²) and with albuminuria UACR ≥ 30–≤ 5 000 mg/g (≥ 3-≤ 500 mg/mmol) associated with T2DM, which are treated with a maximally tolerated dose of ACEi or ARB.

Keywords:

type 2 diabetes mellitus – chronic kidney disease – finerenone

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