The dual GIP and GLP1 receptor agonist tirzepatide: a new effective treatment for type 2 diabetes mellitus

Czech version

Authors: Vladimír Uličiansky
Published in: Diab Obez 2023; 23(45): 9-17
Category: Reviews

Overview

The incretin hormones glucose-dependent insulinotropic polypeptid (GIP) and glucagon-like peptide-1 (GLP-1) have their main physiological role in augmenting insulin secretion after their nutrient-induced secretion from the gut. Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide- 1 receptor agonist (GLP-1 RA) developed for the treatment of type 2 diabetes. Increases insulin sensitivity, improves β-cell function, reduces food intake and increases energy expenditure. Improves metabolic flexibility and nutrient partitioning. Alters adverse event profile vs. GLP-1 RA. The mechanism of action, effectivity and safety profile of tirzepatid potentially fills important gaps in the current treatment of type 2 diabetes mellitus.

Keywords:

dual agonist GIP and GLP-1 receptor (GIP and GLP-1 RA) – glucose-dependent insulinotropic polypeptide (GIP) – glucagon-like peptide-1 (GLP-1) – type 2 diabetes mellitus (DM2T)

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