CD 68 Positivity of the so-called Meconium Corpuscles in Human Foetal Intestine

Czech version

Authors: C. Povýšil; R. Bennett; V. Povýšilová
Authors‘ workplace: Ustav patologie 1. LF UK a VFN, Katedra patologické anatomie IPVZ, Praha Ústav patologické anatomie 2. LF UK a FN Motol, Praha
Published in: Čes.-slov. Patol., , 2001, No. 1, p. 7-9
Category:

Overview

CD 68 antibodies are most frequently used as a reliable paraffin marker of histiocytes. The CD 68 clusters of antibodies recognize a 110-kDa glycoprotein associated with lysosomes and therefore these antibodies show visible reaktivity with cella of the monocyte/macrophage lineage. We obser• ved distinet CD 68 positivity of granular intraepithelial inclusions in the small intestine of 12week-old human foetuses. These PAS positive inclusions corresponded to the so-called meconium particles, whose lysosomal origin was confirmed by electron microscopy. Our new observation shows that CD 68 antibodies are specific mainly for organelles and not for a cell type and therefore the staining of epithelial cella containing lysosomes is possible.

Key words:
meconium corpuscles - foetal intestinal epithelium - CD 68 positivity

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Article was published in

Czecho-Slovak Pathology

2001 Issue 1