#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

On the Problems of the Etiopathogenesis and the Mechanisms of TreatingPorphyria Cutanea Tarda


Authors: L. Malina
Authors‘ workplace: Katedra dermatovenerologie IPVZ, Praha, vedoucí prof. MUDr. F. Vosmík, DrSc.
Published in: Čes-slov Derm, , 2003, No. 5, p. 192-196
Category:

Overview

Porphyria cutanea tarda appears in its familial form with an autosomal dominant transmissionof the defect of uroporphyrinogen decarboxylase in all tissues of the body, or in its sporadic formwith the defect in the liver only, in our population with a prevalence of 1:15.000. Etiologically thereparticipate in its appearance the iron overload (often caused by a mutation of the HFE gene ofhereditary hemochromatosis), chronic alcohol intoxication, long-term estrogen therapy, and hepatitisC infection. Reliable treatments are serial phlebotomies and oral therapy with low doses ofquinoline antimalarial drugs, or the combination of both.The report speaks of factors and conditions for the appearance of the disorder and of themechanisms of the therapeutic action of both the treatments. It also presents a draft of a rationalscheme for the optimal therapy of PCT.

Key words:
porphyria cutanea tarda – iron overload – uroporphyrinogen decarboxylase – HFE genemutation – hepatitis C – alcohol – estrogens – venepuncture – antimalarial drugs

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Dermatology & STDs Paediatric dermatology & STDs
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#