Anemia of prematurity (AOP)
Authors:
K. Demová; M. Kovácsová; O. Zaikina; Š. Macková
Authors‘ workplace:
Neonatologická klinika, Fakultná nemocnica s poliklinikou, Nové Zámky
Published in:
Čes-slov Neonat 2024; 30 (2): 108-113.
Category:
Reviews
Overview
Anemia of prematurity (AOP)
Advances in perinatal and neonatal care have led and continue to increase the survival of premature newborns. Nevertheless, this group of newborns remains at significant risk of developing the most common life-threatening complications, such as intraventricular hemorrhage, necrotizing enterocolitis, retinopathy of prematurity, and anemia of prematurity. Anemia of premature babies is caused by a combination of several factors: lower hemoglobin value at birth, short average life span of red blood cells, reduced production of endogenous erythropoietin, associated medical complications and frequent blood sampling. The summary article summarizes information about the adaptation of erythropoiesis, the causes of anemia of prematurity, the possibilities of its diagnosis, prevention and treatment in the light of current literature.
Keywords:
prevention – erythropoietin – anemia of prematurity – transfusions
Sources
- ACOG. Delayed umbilical cord clamping after birth. Number 814 (Replaces Committee Opinion 684, January 2017. Reaffirmed 2023). Dostupné na: https://www.acog.org/clinical/clinical-gui- dance/committee-opinion/articles/2020/12/delayed-umbilical-cord-clamping-after-birth
- Aher SM, Ohlsson A. Early versus late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database of Systematic Reviews 2020; 2: CD004865. doi: 10.1002/14651858.CD004865.pub4. Accessed 24 February 2024.
- Benavides A, Bell EF, Georgieff MK, Josephson CD, Stowell SR, Feldman HA, Nalbant D, Tereshchenko A, Sola-Visner M, Nopoulos P. Sex-specific cytokine responses and neurocognitive outcome after blood transfusions in preterm infants. Pediatr Res 2022; 91(4): 947−954. doi: 10.1038/s41390-021-01536-0.
- Cibulskis CC, Maheshwari A, Rao R, Mathur AM. Anemia of prematurity: How low is too low? Journal of Perinatology 2021; 41(6): 1244−1257. doi: doi.org/10.1038/s41372-021-00992-0.
- Dečkov I, Záhumenský J, Danihel Ľ, Letkovská K, Varga I. Vývin hematopoetického systému embrya a plodu. Gynekológia pre prax. 2016; 14(3), 121−123. ISSN 1336-3425.
- Deschmann E, Dame C, Sola-Visner MC, et al. Clinical practice guideline for red blood cell transfusion thresholds in very preterm neonates. JAMA Netw Open. 2024;7(6):e2417431. doi:10.1001/jamanetworkopen.2024.17431. Dostupné na: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2820028.
- Domellöf M. Meeting the iron needs of low and very low birth weight infants. Ann Nutr Metab 2017; 71(3): 16−23. doi: 10.1159/000480741.
- DynaMed. Anemia in the premature neonate: Approach to the patient. EBSCO Information Services. Accessed 14. October 2024. Dostupné na: https://www.dynamed.com/approach-to/ anemia-in-the-premature-neonate-approach-to-the-patient.
- Franz AR, Engel C, Bassler D, et al. ETTNO Investigators. Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: The ETTNO randomized clinical trial. JAMA 2020; 324(6): 560−570. doi:10.1001/jama.2020.10690.
- Garcia-Prats JA. Anemia of prematurity. Revised in 2023. Dostupné na: https://www.uptodate.com/contents/ane- mia-of-prematurity-aop?source=mostViewed_widget.
- German KR, Juul SE. Neonatal Anemia. Curr Pediatr Rev 2023; 19(4): 388−394. doi: 10.2174/1573396319666221121140627.
- Hellström W, Forssell L, Morsing E, Sävman K, Ley D. Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia. Acta Paediatr 2020; 109(4): 679−687. doi: 10.1111/apa.15003.
- Chaudhary N, Jassar R, Singh R. Neonatal anemia. Newborn 2022; 1(3): 263–270. doi: 10.5005/jp-journals-11002-0027.
- Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O‘Shea TM, Hartman AL, Heagerty PJ. PENUT Trial Consortium. A randomized trial of erythropoietin for neuroprotection in preterm infants. N Engl J Med 2020; 382(3): 233−243. doi: 10.1056/NEJMoa1907423.
- Kirpalani H, Bell EF, Hintz SR, et al. Eunice Kennedy Shriver NICHD Neonatal Research Network. Higher or lower hemoglobin transfusion thresholds for preterm infants. N Engl J Med 2020; 383(27): 2639−2651. doi:10.1056/ NEJMoa2020248.
- Kling PJ. Iron nutrition, erythrocytes, and erythropoietin in the NICU: Erythropoietic and neuroprotective effects. Neoreviews 2020; 21(2): e80−e88. doi: 10.1542/neo.21-2-e80. PMID: 32005718.
- Madar J, Roehr CC, Ainsworth S, Ersdal H, Morley C, Rüdiger M, et al. European resuscitation council guidelines 2021: Newborn resuscitation and support of transition of infants at birth. Resuscitation 2021; 161: 291−326. doi: 10.1016/j.resuscitation.2021.02.014.
- McCarthy EK, Kenny LC, Hourihane JOB, Irvine AD, Murray DM, Kiely ME. Impact of maternal, antenatal and birth-associated factors on iron stores at birth: data from a prospective maternal-infant birth cohort. Eur J Clin Nutr 2017; 71(6): 782−787. doi: 10.1038/ejcn.2016.255.
- Moreno-Fernandez J, Ochoa JJ, Latunde-Dada GO, DiazCastro J. Iron deficiency and iron homeostasis in low birth weight preterm infants: A systematic review. Nutrients 2019; 11(5): 1090. doi: 10.3390/nu11051090.
- Rabe H, Diaz-Rossello JL, Duley L, Dowswell T. Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database of Systematic Reviews 2012; (8): CD003248. doi: 10.1002/14651858.CD003248.pub3.
- Raffaeli G, Manzoni F, Cortesi V, Cavallaro G, Mosca F, Ghirardello S. Iron homeostasis disruption and oxidative stress in preterm newborns. Nutrients 2020; 12(6): 1554. doi: 10.3390/ nu12061554.
- Scrivens A, Reibel NJ, Heeger L, Stanworth S, Lopriore E, New HV, et al. Survey of transfusion practices in preterm infants in Europe. Arch Dis Child Fetal Neonatal 2023; 108: 360–366. doi: 10.1136/archdischild2022-324619.
- Whitehead NS, Williams LO, Meleth S, Kennedy SM, Ubaka-Blackmoore N, Geaghan SM, Nichols JH, Carroll P, McEvoy MT, Gayken J, Ernst DJ, Litwin C, Epner P, Taylor J, Graber ML. Interventions to prevent iatrogenic anemia: A laboratory medicine best practices systematic review. Crit Care 2019; 23(1): 278. doi: 10.1186/s13054-019-2511-9.
Labels
Neonatology Neonatal NurseArticle was published in
Czech and Slovak Neonatology
2024 Issue 2
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