Immune-related hemolytic anemia of newborns: pathophysiology and diagnosis
Authors:
L. Čaklošová; P. Babušík
Authors‘ workplace:
Novorodenecké oddelenie, Hornooravská nemocnica s poliklinikou, Trstená
Published in:
Čes-slov Neonat 2024; 30 (2): 121-128.
Category:
Reviews
Overview
Immune-related hemolytic anemia of newborns: pathophysiology and diagnosis
Immune hemolytic anemias represent a specific subgroup of extracorpuscular hemolytic anemias in the neonatal period. They are defined by inadequate and excessive hemolysis, which is mediated by antierythrocyte antibodies. Understanding of the processes of physiological and pathological hemolysis, along with the knowledge of immunohematology principles is an essential key for correct diagnosis and successful treatment. The hemolytic disease of the fetus and newborn is well known hemolytic anemia from this group of anemias, with generally accepted diagnostic and treatment procedures. Identification of less frequent immune-related anemias remains a diagnostic and therapeutic challenge. The basis for adequate management of a patient with this type of anemia is essential excellent laboratory diagnostics and mutual cooperation between a neonatologist and a pediatric hematologist.
Keywords:
immune hemolytic anemia – antierythrocyte antibodies – Coombs test
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Neonatology Neonatal NurseArticle was published in
Czech and Slovak Neonatology
2024 Issue 2
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