Kardiovaskulární riziko nesteroidních antirevmatik

English version

Autoři: Štefan Alušík ¹; Zoltán Paluch ²
Působiště autorů: Department of Internal Medicine, Institute for Postgraduate Medical Education, Prague ¹; Department of Pharmacology, Charles University Medical School 2, Prague ²
Vyšlo v časopise: Vnitř Lék 2018; 64(3): 266-271
Kategorie: Přehledné referáty

Souhrn

Nesteroidní protizánětlivé léky (non-steroidal anti-inflammatory drugs – NSAIDs) patří k nejčastěji používaným léčivům. Výsledky rozsáhlých metaanalýz klinických studií publikovaných v posledních letech ukázaly, že kardiovaskulární riziko nesteroidních antirevmatik je závažnější, než se doposud myslelo a není vázáno výlučně na koxiby. Zvyšují ho ale i tzv. tradiční nesteroidní antirevmatika. Z dosavadních poznatků vyplývá, že z pohledu kardiovaskulárního rizika k nejbezpečnějším přípravkům patří naproxen a ibuprofen v malých dávkách. Pozice naproxenu jako nejbezpečnějšího nesteroidního antirevmatika je některými novějšími nálezy poněkud zpochybňována. Autoři přispívají do diskuse o některých výsledcích metaanalýz klinických studií i závěrech regulátorů.

Klíčová slova:
diklofenak – ibuprofen – kardiovaskulární riziko – koxiby –naproxen – nesteroidní antirevmatika

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