Risk of thrombosis in association with oral contraceptive use from hematologist΄s point of view

Česká verze

Authors: Petr Dulíček ¹ ; Eva Ivanová ¹; Petr Sadílek ¹; Martin Beránek ²
Authors place of work: IV. interní hematologická klinika, LF UK a FN, Hradec Králové ¹; Ústav klinické biochemie a diagnostiky, LF UK a FN, Hradec Králové ²
Published in the journal: Prakt Gyn 2013; 17(4): 277-282
Category: Gynekologie a porodnictví: Přehledový článek

Trombotické komplikace jsou více než 50 let dobře známou komplikací užívání hormonální antikoncepce. Riziko je jak pro trombózu žilní, tak arteriální. Příčiny trombóz jsou velmi často multifaktoriální a závisí na celé řadě dalších rizikových faktorů. V článku se zabýváme zejména rizikovostí vrozených trombofilních stavů, a to především mutací FV Leiden a mutací FII 20210a. Hormonální antikoncepce patří mezi časté příčiny trombózy u žen v produktivním věku, nicméně správným zhodnocením všech dalších rizikových faktorů a zajištěním všech rizikových situací je možné toto riziko snížit.

Summary

Thrombotic diathesis is more than 50 years well known complication of oral contraceptive use. The risk is not only for venous thrombosis, but also for arterial one. Etiology is usually a multifactorial and depends on a several additional risk factors. We discuss the role of inherited thrombophilia with the focus on F V Leiden mutation and FII20210a mutation. Hormonal contraception use belongs among very frequent causes of thrombosis in female in reproductive age. However, this risk is possible to decrease after appropriate assessment of all additional risk factors and due to thromboprophylaxis in risk situations.

Key words:
hormonal contraceptive pill – thrombophilia – venous thromboembolism

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