#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

EN

Expression of Concern: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

Download PDF České info

article has not abstract

Published in the journal: . PLoS Genet 11(6): e32767. doi:10.1371/journal.pgen.1005377
Category: Expression of Concern
doi: https://doi.org/10.1371/journal.pgen.1005377

Summary

article has not abstract

Concerns have been raised regarding some of the data in the PLOS Genetics article “RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells”, notably in panel A in Fig 4, in panels A and F in S4 Fig, and with the statistical analyses used to produce Fig 2. The authors have responded to these concerns, acknowledging that some errors were made in figure preparation and with some statistical tests, however a final resolution has not yet been reached, and the matter is being evaluated by the authors’ institution.

This Expression of Concern should not be considered as a statement regarding validity of the work but rather as a notification to readers, and an intent to provide additional information as it becomes available.

Zdroje

1. Ciaudo C, Jay F, Okamoto I, Chen C-J, Sarazin A, Servant N, et al. (2013) RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells. PLoS Genet 9(11): e1003791. doi: 10.1371/journal.pgen.1003791 24244175

Štítky

Genetika Reprodukční medicína

Článek Orphan Genes Find a Home: Interspecific Competition and Gene Network Evolution

Článek Minor Cause—Major Effect: A Novel Mode of Control of Bistable Gene Expression

Článek Germline Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia

Článek Leveraging Identity-by-Descent for Accurate Genotype Inference in Family Sequencing Data

Článek Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Retina

Článek Epigenetic Aging Signatures Are Coherently Modified in Cancer

Článek Silencing of DNase Colicin E8 Gene Expression by a Complex Nucleoprotein Assembly Ensures Timely Colicin Induction

Článek A Transposable Element within the Non-canonical Telomerase RNA of Modulates Telomerase in Response to DNA Damage

Článek The Orphan Gene Regulates Dauer Development and Intraspecific Competition in Nematodes by Copy Number Variation

Článek 9--13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

Článek The DnaA Protein Is Not the Limiting Factor for Initiation of Replication in

Článek FGFR3 Deficiency Causes Multiple Chondroma-like Lesions by Upregulating Hedgehog Signaling

Článek Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease

Článek Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination

Článek The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

Článek MreB-Dependent Inhibition of Cell Elongation during the Escape from Competence in

Článek DNA Damage Regulates Translation through β-TRCP Targeting of CReP

Článek Multiple In Vivo Biological Processes Are Mediated by Functionally Redundant Activities of and

Článek The Analysis of () Mutants Reveals Differences in the Fusigenic Potential among Telomeres

Článek The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in .

Článek Temporal Expression Profiling Identifies Pathways Mediating Effect of Causal Variant on Phenotype

Článek The . Accessory Helicase PcrA Facilitates DNA Replication through Transcription Units

Článek AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

Článek Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status

Článek Transfer RNAs Mediate the Rapid Adaptation of to Oxidative Stress

Článek Connecting Circadian Genes to Neurodegenerative Pathways in Fruit Flies

Článek Response to “Ribosome Rescue and Translation Termination at Non-standard Stop Codons by ICT1 in Mammalian Mitochondria”

Článek Response to the Formal Letter of Z. Chrzanowska-Lightowlers and R. N. Lightowlers Regarding Our Article “Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria”

Článek Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

Článek Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins

Článek Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

Článek Non-reciprocal Interspecies Hybridization Barriers in the Capsella Genus Are Established in the Endosperm

Článek Canine Spontaneous Head and Neck Squamous Cell Carcinomas Represent Their Human Counterparts at the Molecular Level

Článek Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and between Species

Článek Functional Assessment of Disease-Associated Regulatory Variants Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

Článek Translational Upregulation of an Individual p21 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

Článek Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy

Článek The Human Blood Metabolome-Transcriptome Interface

Článek A Common Cancer Risk-Associated Allele in the Locus Encodes a Dominant Negative Inhibitor of Telomerase

Článek A Legume Genetic Framework Controls Infection of Nodules by Symbiotic and Endophytic Bacteria

Článek The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in

Článek The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan

Článek Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Článek Exome Sequencing of Phenotypic Extremes Identifies and as Interacting Modifiers of Chronic Infection in Cystic Fibrosis

Článek The Role of -Mediated Epigenetic Silencing in the Population Dynamics of Transposable Elements in

Článek Ancestral Chromatin Configuration Constrains Chromatin Evolution on Differentiating Sex Chromosomes in

Článek Abnormal Activation of BMP Signaling Causes Myopathy in Null Mice

Článek Reproductive Mode and the Evolution of Genome Size and Structure in Nematodes

Článek Replication and Active Partition of Integrative and Conjugative Elements (ICEs) of the SXT/R391 Family: The Line between ICEs and Conjugative Plasmids Is Getting Thinner

Článek Motor and Sensory Deficits in the Mice Result from Mutation of the ESCRT Component HGS

Článek Senescence in the Sbds-Deficient Murine Pancreas: Cell-Type Specific Consequences of Translation Insufficiency

Článek Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake

Článek Separable Crossover-Promoting and Crossover-Constraining Aspects of Zip1 Activity during Budding Yeast Meiosis

Článek Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4

Článek Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth

Článek Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms

Článek A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence

Článek vyšel v časopise

PLOS Genetics

2015 Číslo 6

Nejčtenější tento týden

Nejčtenější v tomto čísle

Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

plice

INSIGHTS from European Respiratory Congress

nový kurz

Současné pohledy na riziko v parodontologii

Autoři: MUDr. Ladislav Korábek, CSc., MBA

Svět praktické medicíny 3/2024 (znalostní test z časopisu)

Kardiologické projevy hypereozinofilií

Autoři: prof. MUDr. Petr Němec, Ph.D.

Střevní příprava před kolonoskopií

Autoři: MUDr. Klára Kmochová, Ph.D.

Kurzy

Podcasty

Doporučená témata

Časopisy

#ADS_BOTTOM_SCRIPTS#