Imunohistologický průkaz mamaglobinu v diferenciální diagnostice mezi apokrinním karcinomem kůže a kožní metastázou karcinomu prsu

English version

Autoři: A. Fernandez-Flores
Působiště autorů: Service of Cellular Pathology, Clinica Ponferrada, Ponferrada, Spain
Vyšlo v časopise: Čes.-slov. Patol., 45, 2009, No. 4, p. 108-112
Kategorie: Původní práce

Souhrn

Diferenciální diagnóza mezi apokrinním karcinomem kůže (AKK) a kožní metastázou karcinomu prsu je často obtížná. Spíše než imunohistologie může pomoci klinická informace.

Použili jsme protilátku mamaglobin k vyšetření 10 případů kožní metastázy duktálního karcinomu prsu a 2 případů AKK. V jednom z případů AKK byly pozitivní jen ojedinělé buňky, druhý případ byl negativní. Z 10 případů metastázy karcinomu prsu byly v 5 pozitivní buňky četné (až 60 % nádorových buněk), ve 4 byly pozitivní ojedinělé buňky a 1 případ byl negativní.

Jsme si vědomi, že by bylo v budoucnu vhodné vyšetřit více případů AKK než bude možno vyslovit kategorický závěr; naše výsledky však ukazují, že imunohistologický průkaz exprese mamaglobinu v četných buňkách nádoru může svědčit pro jeho metastatický původ.

Klíčová slova:
mamaglobin – karcinom apokrinní žlázky – metastatický karcinom – duktální karcinom – prs

Zdroje

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