Pohľad na klasifi káciu a manažment endometriálneho karcinómu v kontexte molekulárnych subtypov

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Autoři: Zuzana Ballová ; Petra Gašparová ; Martina Sitáš ; Erik Dosedla
Působiště autorů: Department of Gynaecology and Obstetrics, Faculty of Medicine, University P. J. Safarik in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic
Vyšlo v časopise: Ceska Gynekol 2024; 89(2): 128-132
Kategorie: Přehledová práce
doi: https://doi.org/10.48095/cccg2024128

Souhrn

Karcinóm endometria je najčastejším gynekologickým karcinómom a druhým najčastejším ženským zhubným nádorom v rozvinutom svete. Zvyčajne sa diagnostikovaný u žien po menopauze s typickým klinickým obrazom abnormálneho krvácania z maternice. V minulosti sa na základe histologického hodnotenia zvažovali iba dva typy. Endometriálny karcinóm je však klinicky heterogénne ochorenie a je čoraz jasnejšie, že táto heterogenita môže byť hybnou silou pri určení rôznorodosti na základe molekulárnych zmien. The Cancer Genome Atlas klasifikačný systémy zlepšil diagnostiku, stratifikáciu rizika a manažment endometriálneho karcinómu popisom štyroch molekulárnych podskupín s rôznou mutačnou záťažou a zmenami v počte kópií.

Klíčová slova:

p53 – endometriálny karcinóm – molekulárna klasifikácia – POLE mutácia – The Cancer Genome Atlas Research Network – hysterektómia – cielená terapia – mismatch-repair

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ORCID authors

Z. Ballová 0000-0002-0605-948X

P. Gašparová 0000-0002-6354-6911

M. Sitáš 0000-0002-7273-1051

E. Dosedla 0000-0001-8319-9008

Submitted/Doručené: 18. 10. 2023

Accepted/Prijaté: 20. 10. 2023

Assoc. Prof. Erik Dosedla, MD, PhD, MBA

Department of Gynaecology and Obstetrics

Faculty of Medicine

University P. J. Safarik in Košice

Hospital AGEL Košice-Šaca Inc.