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Chemoimmunotherapy in the Treatment of Breast Cancer −⁠ Final Results of the IMpassion130 Study

25. 10. 2020 Source: Breast Carcinoma

According to international recommendations, treatment with the immune checkpoint inhibitor atezolizumab in combination with the cytostatic nab-paclitaxel is used for patients with locally advanced or metastatic breast cancer where PD-L1 protein expression is detected on the surface of tumor-infiltrating immune cells (IC). The final results regarding overall survival and long-term safety of this treatment in patients who participated in the registration study IMpassion130 were presented at this year's European Society for Medical Oncology…

Onkologická pozitivní pacientka

Fixed Combination of Trastuzumab and Pertuzumab for Subcutaneous Administration in Patients with Early Breast Cancer

At a symposium focused on breast cancer, held in December 2019 in San Antonio, Texas, preliminary results of the FeDeriCa clinical study were presented –⁠ comparing the pharmacokinetics, efficacy, and…
25. 10. 2020 Source: Breast Carcinoma
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Dysregulation of microRNA Expression After Treatment with Anti-EGFR Antibodies

A team of researchers from Plzeň decided to verify whether treatment with anti-EGFR antibodies changes the expression of selected microRNAs in patients with metastatic colorectal carcinoma (mCRC).…
22. 10. 2020 Source: Colorectal Cancer
Results

Panitumumab in 1st Line in Older Patients –⁠ Results of the PANDA Study

The phase II PANDA study evaluated the regimens FOLFOX + panitumumab versus 5-FU + panitumumab in the 1st line treatment of patients with wt-RAS/BRAF metastatic colorectal cancer (mCRC).
22. 10. 2020 Source: Colorectal Cancer
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Dupilumab in the Treatment of Severe Asthma in Real-World Practice

A freshly published French study is the first to confirm the results of clinical trials with dupilumab in patients with severe asthma in real-world practice.
20. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
atopicka_dermatitida_na_rukou_vyrazka

Treatment of Comorbidities of Atopic Dermatitis in One Go and Where to Refer Candidates for Biologic Therapy

Patients suffering from atopic dermatitis (AD) along with allergic comorbidities typically require a fairly complex pharmacotherapy to manage their difficulties. However, their everyday lives can be…
19. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation

Metformin −⁠ A Proven Helper That Effectively Protects the Heart of Diabetics

Metformin is one of the first-line medications for patients with type 2 diabetes. In addition to lowering blood glucose levels, it also affects other metabolic processes in the human body. Its…
19. 10. 2020 Source: Modern Treatment of Diabetes
leky_medikace_vyber_doporuceni_preskripce

Prescription Restrictions on Antidiabetics Authorized for Prescription by General Practitioners -⁠ Status as of October 2020

Diabetes mellitus (DM) has become an increasing problem worldwide in recent years. Long-term complications of DM lead to increased morbidity and mortality in the diabetic population, and their…
15. 10. 2020 Source: Diabetes
Kyselina obeticholová

Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice

An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and…
14. 10. 2020 Source: Primary Biliary Cholangitis

Nutritional Care as Part of Prehabilitation in Surgical Patients

Nutritional preparation of patients before surgery as part of prehabilitation can significantly affect the quality of recovery and physical condition of patients after surgery. This topic is…
14. 10. 2020 Source: Enteral Nutrition
Pomocné_ruce

Memantine and Donepezil –⁠ Unity is Strength

Memantine and donepezil are both used in the therapy of Alzheimer's disease (AD). However, how does the combination of these drugs fare in the treatment of moderate to severe AD?
12. 10. 2020 Source: Cognitive in the treatment of Alzheimer's disease
alzheimer 88

Memantine Eases Daily Life for Patients and Caregivers

What is the efficacy and safety of memantine in patients with Alzheimer's disease in routine practice in the Czech Republic? And to what extent can it ease the burden on caregivers of these patients?
12. 10. 2020 Source: Cognitive in the treatment of Alzheimer's disease
kvalita života

What impact do the symptoms of primary biliary cholangitis have on the patient and their quality of life

Primary biliary cholangitis (PBC) is a serious chronic cholestatic autoimmune liver disease that predominantly affects middle-aged women and can lead to end-stage liver failure and the need for…
12. 10. 2020 Source: Primary Biliary Cholangitis
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Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases

Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the…
11. 10. 2020 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
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Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients

Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently…
9. 10. 2020 Source: Pharmacotherapy of Pain
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