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Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?
The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest possible vector dose. Updated data from a study examining the use of the adeno-associated viral vector (AAV) SPK-8011 were presented during the virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021.
Von Willebrand Disease in Women
Even in the context of gynecological issues, it is sometimes necessary to consider a hematological…
Biosimilar Drugs in Oncology
8 of the 10 most expensive drugs on the market are used in the treatment of cancer. Rising…
Pharmacotherapy of Chronic Heart Failure with Reduced EF LV - Latest ESC Recommendations
The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment…
Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures
The possibility of actively preventing severe bleeding after a major cardiac surgical procedure…
Neutralizing Antibodies Against Emicizumab – Detailed Analysis Based on a Case Study
Japanese authors investigated the mechanism of reduced efficacy of emicizumab in an adult patient…
HAE and its Management in Pediatric Patients
Hereditary angioedema (HAE) can be encountered in the emergency room as well as in specialist practices....
HAE in the Otolaryngologist's Office: How to Handle a Laryngeal Attack?
Hereditary angioedema (HAE) can be encountered in emergency rooms and specialist offices. Patients with...
Cell-Based Implant as a Stable System for Biological Therapy Delivery
A team of scientists from Washington University in St. Louis focused on the possibility of…
Comparable Long-term Safety of Tofacitinib and Biologics in RA Treatment – Data from a US Registry
An analysis of the long-term safety profile of tofacitinib in real clinical practice was published…
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