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News Possibilities of Cannabis Use in Tourette Syndrome Therapy
A retrospective analysis and online survey conducted at a psychiatric clinic in Hanover, Germany, investigated the effectiveness and safety of using cannabis products in patients with Tourette syndrome in real-world practice.
News Interactive Case Study: Treatment of Neuropathic Pain in a Patient with Neurodegenerative Disease
We offer a brief case study of a polymorbid patient suffering from chronic pain, spasticity, and sleep disturbances, among other issues. Medical cannabis was advantageously introduced, helping to alleviate several symptoms. You can interactively explore how you would proceed in this case.
News Comparison of Clinical Outcomes of TKA Implantation: ATTUNE vs. SIGMA
The ATTUNE total knee arthroplasty (TKA) system was introduced to the market in 2013 as a successor to the popular SIGMA system. The new type of knee endoprosthesis is designed to provide better stability and mobility than the previous implant. Several studies have evaluated the clinical outcomes of the implantation of both types of endoprostheses.
News Relationship between Thyroid Gland Echogenicity and Its Function in Pediatric Patients with Hashimoto's Thyroiditis
Hashimoto's (chronic lymphocytic) thyroiditis is the most common cause of acquired hypothyroidism in both adults and pediatric patients in developed countries. The study presented below explored the relationship between thyroid gland (TG) echogenicity observed in ultrasound (US) examinations and its function in patients diagnosed with this condition.
News Dupilumab – The First Biologic Umbrellaing Type 2 Inflammation Treatment: How Does It Work and Who Is It For?
A new drug is entering the market for the treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps – the biologic product Dupixent®. The active ingredient is dupilumab, a fully human monoclonal antibody administered subcutaneously using a pre-filled syringe.
News Role of Transthyretin in the Development of Amyloidosis
Transthyretin (TTR), one of the transport proteins, tends to form extracellular deposits that accumulate in key organs, such as the heart and nerves. The formation of TTR deposits leads to the development of systemic amyloidosis, a disease with highly heterogeneous clinical manifestations. Warning signs may include carpal tunnel syndrome, among others. What is the physiological role of TTR in the body and what role does its structure play in the development of amyloidosis?
News How to Reduce the Risk of Venous Thromboembolism in Users of Combined Hormonal Contraceptives?
The use of combined oral contraceptives (COCs) is a known risk factor for thromboembolism. Therefore, we should consider the individual risk of each patient before prescribing COCs. Women with a positive personal or family history of thromboembolic events should undergo molecular genetic testing for the presence of thrombophilic mutations.
News Effect of Administering Ferric Carboxymaltose on Quality of Life in Heart Failure Patients
The quality of life in patients with heart failure is significantly reduced. The concurrent occurrence of iron deficiency further exacerbates this situation. The AFFIRM-AHF study evaluated the impact of intravenous administration of ferric carboxymaltose on health-related quality of life (HRQoL) in patients with heart failure who also suffered from iron deficiency.
News Can we properly manage osteoporotic fractures?
Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in patients after fractures and subsequently set appropriate therapy.
News Subcutaneous zilucoplan – the end of necessary “trips” to the hospital for myasthenia gravis patients?
A study recently published in Lancet Neurology demonstrated the efficacy and safety of the subcutaneously administered complement component C5 inhibitor – zilucoplan – in the treatment of myasthenia gravis (MG). This drug has the potential to alleviate the severity of this disease and improve the quality of life of patients.
News Complete remission of ALK-positive lung cancer in a patient after multiple lines of targeted therapy – a case study
Targeted treatment for driving oncogenic mutations has significantly improved outcomes for patients with ALK-positive non-small cell lung cancer (NSCLC) as well. A case study was recently published in the journal Frontiers in Oncology of a patient with advanced disease who achieved complete remission after several lines of therapy.
News Spectrum of Mechanisms of Action of Fenfluramine in the Treatment of Rare Epilepsies
Fenfluramine (FFA) is an anticonvulsant used in the treatment of rare epilepsies such as Dravet syndrome and Lennox-Gastaut syndrome. In addition to effectively reducing seizure frequency, it also mitigates non-seizure comorbidities in patients with these conditions. Last year, Belgian authors published a detailed review of all its described mechanisms of action. They also explain how these mechanisms might contribute to the clinical benefits of FFA beyond seizure suppression, such as reducing the risk of sudden unexpected death in epilepsy (SUDEP) or improving executive functions.
News Reimbursement vs. Indication: Are They Clashing in Alzheimer's Disease?
Data from clinical trials and recommended procedures do not always align with insurance reimbursement criteria. Is this the case with Alzheimer's disease treatment?
News Psychiatry of Transitional Age − An Important Area That Has Not Yet Received Much Attention
Three-quarters of psychiatric disorders develop before the age of 25, with up to half of these disorders appearing before the age of 16. The period of so-called emerging adulthood thus represents a key phase in psychiatry. Unfortunately, due to the separate development of child and adult psychiatry, this area has not yet received sufficient attention, and so-called transitional psychiatry is still in its infancy.
News Long-term survival of a 50-year-old man with metastatic pancreatic cancer on a combination of nal-IRI + 5-FU/LV in 2nd line treatment − case study
A recently published case study from the Czech Republic describes a patient with progression of pancreatic cancer following surgical treatment and adjuvant chemotherapy, who achieved a one-year survival with good quality of life on a combination of nal-IRI + 5-FU/LV after the failure of gemcitabine + nab-paclitaxel in the 1st line of palliative treatment.
News INFOGRAPHIC: Mavacamten in the treatment of obstructive hypertrophic cardiomyopathy
Obstructive hypertrophic cardiomyopathy (HCM) is most commonly caused by disorders of cardiac muscle proteins. How does targeted treatment for this disease work? We bring a concise, graphically processed overview of the efficacy and mechanism of action of the first selective cardiac myosin inhibitor.
News Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome
Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of concomitant cardiomyopathy is not yet fully understood. Japanese researchers from Kumamoto University recently focused on the relationship between carpal tunnel syndrome and cardiac amyloidosis in their newly published prospective study.
News Combination of SGLT2 inhibitors with metformin in terms of mechanism of action
In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2 inhibitors (SGLT2i) are recommended in combination with metformin in light of recent findings, as their mechanism of action is independent of insulin effect. They have shown a reduction in cardiovascular (CV) risk in diabetics with CV disease.
News Incidence of Osteoporosis in Patients with Atrial Fibrillation Treated with Different Oral Anticoagulants
Previous research has suggested an increased risk of osteoporosis and osteoporotic fractures in patients with atrial fibrillation treated with warfarin. A recent analysis also identified a higher incidence of osteoporosis in patients treated with warfarin or direct oral anticoagulants (DOACs). However, less is known about the risk of this disease when using DOACs compared to warfarin. Therefore, Australian doctors compared its incidence in patients treated with different oral anticoagulants for atrial fibrillation (AF) in a population cohort study using data from a nationwide primary care database.
News Initial Treatment for Newly Diagnosed ITP Patients at a Glance
The revised international consensus on the management of primary immune thrombocytopenia (ITP) from 2019 outlines several points summarizing suitable initial treatment for newly diagnosed individuals with ITP.
News Scientists Create First Functional Brain Tissue Using 3D Printing
A research team from the University of Wisconsin-Madison has successfully printed the first ever functional brain tissue using a commercial 3D printer in their laboratory. This breakthrough may be beneficial not only for scientists studying the pathogenesis of neurological and neurodevelopmental diseases but could even mark the beginning of a journey towards a deeper understanding of how neurons function, how brain development occurred, and how different parts of the brain communicate with each other.
News Lung Recovery After COVID-19: How Reversible is the Damage?
During the virtual XXV Hradec Pulmonology Days held in April 2021, various aspects concerning COVID-19 were among the major topics. Dr. Bram van den Borst from Radboud University Nijmegen provided a comprehensive summary of current insights regarding lung recovery following an infection.