Advancements in the treatment of adult acute lymphoblastic leukaemia
Authors:
Š. Hrabovský 1; F. Folber 1; C. Šálek 3; J. M. Horáček 4; J. Mayer 1,2; M. Doubek 1,2
Authors‘ workplace:
Interní hematologická a onkologická klinika, LF MU a FN Brno
1; Středoevropský technologický institut (CEITEC), LF MU Brno
2; Ústav hematologie a krevní transfuze, Praha
3; IV. interní hematologická klinika, FN Hradec Králové a Katedra vojenského vnitřního lékařství a vojenské hygieny, FVZ UO Hradec Králové
4
Published in:
Transfuze Hematol. dnes,21, 2015, No. 2, p. 84-91.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
Acute lymphoblastic leukaemia (ALL) is predominantly a childhood disease and its incidence in adults is low. The prognosis and treatment outcome in adults are less satisfactory than in children. However, many new discoveries have been made recently. This review describes diagnostic procedures and treatment options in adult ALL. It focuses on minimal residual disease and its prognostic significance; on several new genetic abnormalities, such as IKZF1 (Ikaros) and NOTCH1 gene mutations and on the new prognostic categories of Ph-like (BCR-ABL1-like) ALL and early T-cell precursor (ETP) ALL. An overview of new drugs currently being tested in clinical trials, especially monoclonal antibodies and antibody-drug conjugates, is also presented.
Key words:
acute lymphoblastic leukaemia, minimal residual disease, BCR-ABL-like ALL, Ikaros, NOTCH1, ETP-ALL, monoclonal antibodies
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Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2015 Issue 2
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