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Zajištění operačních výkonů u pacientů s von Willebrandovou chorobou preparátem Wilate® – první klinické zkušenosti jednoho centra v ČR


Authors: R. Hrdličková 1;  Š. Blahutová 1;  O. Šimetka 2;  J. Zuchnická 3;  Z. Čermáková 2
Authors‘ workplace: Krevní centrum Fakultní nemocnice Ostrava 1;  Lékařská fakulta Ostravské univerzity 2;  Ústav klinické hematologie Fakultní nemocnice Ostrava 3
Published in: Transfuze Hematol. dnes,18, 2012, No. 4, p. 165-168.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

The authors introduce first experiences of their centre with perioperative management of three patients with von Willebrand disease (type 1, type 2 and acquired von Willebrand syndrom) by replacement therapy with Wilate®, which is a new generation of plasma concentrate vWF/FVIII with high-purity and double virus inactivation. In all our cases, Wilate® was effective for maintaining haemostasis and prevention of bleeding from soft tissues and mucous.

Key words:
von Willebrand disease, perioperative bleeding, Wilate®


Sources

1. Nichols WL, Hultin MB, James AH, et al. Von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia 2008; 14: 171–232.

2. Smejkal P, Matýšková M, Penka M. Von Willebrandova choroba. Vnitř Lék 2008; 257–264.

3. Stadler M, Gruber G, Kannicht C, et al. Characterization of novel high purity, double virus inactivated von Willebrand factor and factor VIII concentrate (Wilate). Biologicals 2006; 34: 281–288.

4. Kessler CM, Friedman K, Schwartz AB, et al. The pharmacokinetic diversity of two von Willebrand factor (VWF) / factor VIII (FVIII) concentrates in subjects with congenital von Willebrand disease. Tromb Haemost 2011; 106 (2): 279–288.

5. Windyga J, Prondzinski M, et al. Efficacy and safety of new generation von Willebrand factor/factor VIII concentrate (Wilate®) in the management of perioperative haemostasis in von Willebrand disease patients undergoing surgery. Tromb Haemost 2011; 105: 1072–1079.

6. Mannucci PM, Federici AB, James AH, Kessler CM. Von Willebrand disease in the 21st century: current approaches and new challenges. Haemophilia 2009; 15: 1154–1158.

7. Mannucci PM. Treatment of von Willebrand´s disease. N Engl J Med 2004; 351: 683–694.

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Haematology Internal medicine Clinical oncology
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