Supportive therapy with megestrol acetate in myeloproliferative neoplasms

Czech version

Authors: J. Hubáček; E. Faber; K. Indrák
Authors‘ workplace: Hemato-onkologická klinika, LF UP a FN Olomouc
Published in: Transfuze Hematol. dnes,18, 2012, No. 4, p. 174-176.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

We present three cases of patients with myeloproliferative neoplasm that were because of anorexia and weight reduction given megestrol acetate to improve their alimentation and so their life quality. Clinically important reduction of splenomegaly and reduction or loss of transfusion dependence after administration of gestagen were observed as side effect in all patients. After discontinuation the spleen started to grow again, but administration of megestrol has led to its repeated diminution. This is the first description of the important „side effect“ of megestrol in patients with myeloproliferative neoplasms and prominent splenomegaly.

Key words:
splenomegaly, myeloproliferative neoplasm, megestrol acetate, transfusion dependence

Sources

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Labels

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Article was published in

Transfusion and Haematology Today

2012 Issue 4