#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Journal of Czech Physicians / 2024 - 7-8

Young adult cancer patients in the Czech Republic: Is there a need for national guidelines?

Czech version

Authors: Tomáš Sokop 1;  David Dufek 1;  Kristýna Polášková 2;  Klára Nováková 2, 3;  Radek Lakomý 1;  Katarína Petráková 1;  Radka Lordick Obermannová 1
Published in: Čas. Lék. čes. 2024; 163: 296-303
Category: Review Article

Overview

Adolescents and young adults (AYAs) are a group of patients characterized by specific needs in cancer care. Although only 5 % of cancers are diagnosed in this age group, malignancies represent a significant burden in terms of years of healthy life lost and the consequences of cancer treatment. Important issues for young patients include diagnostic delay, promotion of primary prevention, biologically distinct tumor types, oncogenetic evaluation, unique psychosocial challenges, fertility issues, monitoring of adverse effects of treatment including the development of secondary malignancies, or the absence of age-specific clinical trials.

The centralization of care and the formation of multidisciplinary teams dedicated to young patients will allow for a more comprehensive approach with a focus on these issues. One means of improving care for young cancer patients is the development of national guidelines and the organisation of international and national clinical trials.

Keywords:

cancer care, young adults, diagnostic delay, psychosocial support, fertility, clinical trials

Sources
  1. Mountzios G, Bielack SS, Mehra N (eds.). ESMO Handbook of Cancer in Adolescents and Young Adults. ESMO Press, Lugano, 2022.
  2. Mountzios G, Douillard JY. Adolescents and young adults with cance: the pathway of care. In: Mountzios G, Bielack SS, Mehra N (eds.). ESMO Handbook of Cancer in Adolescents and Young Adults. ESMO Press, Lugano, 2022: 1–9
  3. Kocarnik JM, Compton K, Dean FE et al. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the Global Burden of Disease Study 2019. JAMA Oncol 2022; 8: 420.
  4. Novotvary 2018 ČR. ÚZIS ČR. Dostupné na: www.uzis.cz/res/f/008352/novotvary2018.pdf
  5. Trama A, Stark D, Bozovic-Spasojevic I et al. Cancer burden in adolescents and young adults in Europe. ESMO Open 2023; 8: 100744.
  6. Zdravotnická ročenka České republiky 2021. ÚZIS ČR. Dostupné na: www.uzis.cz/index.php?pg=vystupy--knihovna&id=275
  7. WHO methods and data sources for global burden of disease estimates 2000–2019. WHO, 2019. Dostupné na: http://cdn.who.int/media/docs/default-source/gho-documents/global-health-estimates/ghe2019_daly-methods.pdf?sfvrsn=31b25009_7
  8. Alvarez EM, Force LM, Xu R et al. The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Oncol 2022; 23: 27–52.
  9. Veneroni L, Mariani L, Lo Vullo S et al. Symptom interval in pediatric patients with solid tumors: adolescents are at greater risk of late diagnosis: late diagnosis in adolescents. Pediatr Blood Cancer 2013; 60: 605–610.
  10. Herbert A, Lyratzopoulos G, Whelan J et al. Diagnostic timeliness in adolescents and young adults with cancer: a cross-sectional analysis of the BRIGHTLIGHT cohort.  Lancet Child Adolesc Health 2018; 2: 180–190.
  11. Bajčiová V. Diagnostika nádorů u mladých dospělých – jaká je role lékaře primárního kontaktu? Medicína pro praxi 2018; 15: 93–97.
  12. Lethaby CD, Picton S, Kinsey SE et al. A systematic review of time to diagnosis in children and young adults with cancer. Arch Dis Child 2013; 98: 349–355.
  13. Van Der Graaf WTA, Orbach D, Judson IR Ferrari A. Soft tissue sarcomas in adolescents and young adults: a comparison with their paediatric and adult counterparts. Lancet Oncol 2017; 18: e166–e175.
  14. Bertuzzi AF, Grimaudo MS, Laffi A et al. Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high‐volume cancer center. Cancer Med 2023; 12: 16254–16263.
  15. Jin Z, Griffith MA, Rosenthal AC. Identifying and meeting the needs of adolescents and young adults with cancer. Curr Oncol Rep 2021; 23: 17.
  16. Chatsirisupachai K, Lagger C, De Magalhães JP. Age-associated differences in the cancer molecular landscape. Trends Cancer 2022; 8: 962–971.
  17. Saloustros E, Tsapakidis K. The unique molecular biology and cancer genetics in adolescents and young adults. In: Mountzios G, Bielack SS, Mehra N (eds.). ESMO Handbook of Cancer in Adolescents and Young Adults. ESMO Press, Lugano, 2022: 45–51.
  18. Metelková A, Skálová A, Fínek J. Karcinom prsu u mladých žen – korelace klinických, histomorfologických a molekulárně-genetických znaků karcinomu prsu u žen mladších 35 let. Klinická onkologie 2017; 30: 202–209.
  19. Kim HJ, Kim S, Freedman RA, Partridge AH. The impact of young age at diagnosis (age <40 years) on prognosis varies by breast cancer subtype: A U.S. SEER database analysis. Breast 2022; 61: 77–83.
  20. Lumish MA, Cercek A. Practical considerations in diagnosing and managing early-onset GI cancers. J Clin Oncol 2022; 40: 2662–2680.
  21. Sokop T, Selingerova I, Obermannova R. 1579P. Gender differences and worse metastatic survival outcomes in young adult patients with oesophagogastric cancer: 12-year data from a Czech comprehensive cancer center. Ann Oncol 2023; 34 (Suppl. 3): S880.
  22. Rahangdale L, Mungo C, O’Connor S et al. Human papillomavirus vaccination and cervical cancer risk. BMJ 2022; 379: e070115.
  23. WHO Cervical Cancer Elimination Initiative: from call to action to global movement. WHO, 2023. Dostupné na: www.who.int/publications/m/item/who-cervical-cancer-elimination-initiative--from-call-to-action-to-global-movement
  24. Boardman LA, Vilar E, You YN, Samadder J. AGA clinical practice update on young adult – onset colorectal cancer diagnosis and management: expert review. Clin Gastroenterol Hepatol 2020; 18: 2415–2424.
  25. Loono. Dostupné na: www.loono.cz
  26. Sekce mladých onkologů ČLS JEP. Dostupné na: www.linkos.cz/ceska-onkologicka-spolecnost-cls-jep/organizace-cos/odborne-sekce-cos/sekce-mladych-onkologu/p/3
  27. Kent EE, Sender LS, Morris RA et al. Multilevel socioeconomic effects on quality of life in adolescent and young adult survivors of leukemia and lymphoma. Qual Life Res 2013; 22: 1339–1351.
  28. Husson O, Ligtenberg MJL, Van De Poll-Franse LV et al. Comprehensive assessment of incidence, risk factors, and mechanisms of impaired medical and psychosocial health outcomes among adolescents and young adults with cancer: protocol of the prospective observational COMPRAYA cohort study. Cancers 2021; 13: 2348.
  29. Altherr A, Bolliger C, Kaufmann M et al. Education, employment, and financial outcomes in adolescent and young adult cancer survivors – a systematic review. Cur Oncol 2023; 30: 8720–8762.
  30. Schulte FSM, Chalifour K, Eaton G, Garland SN. Quality of life among survivors of adolescent and young adult cancer in Canada: a young adults rith cancer in their prime (YACPRIME) study. Cancer 2021; 127: 1325–1333.
  31. Fuck Cancer. Dostupné na: www.fuckcancer.cz
  32. Wu XC, Prasad PK, Landry I et al. Impact of the AYA HOPE comorbidity index on assessing health care service needs and health status among adolescents and young adults with cancer. Cancer Epidemiol Biomarkers Prev 2015; 24: 1844–1849.
  33. Rugbjerg K. Short- and long-term toxicities of treatment in survivors of adolescent and young adult cancer. In: Mountzios G, Bielack SS, Mehra N (eds.). ESMO Handbook of Cancer in Adolescents and Young Adults. ESMO Press, Lugano, 2022: 178–192.
  34. Modrá kniha České onkologické společnosti ČLS JEP. Dostupné na: www.linkos.cz/lekar-a-multidisciplinarni-tym/personalizovana-onkologie/modra-kniha-cos/aktualni-vydani-modre-knihy
  35. Dušek L, Mužík J, Kubásek M et al. Epidemiologie zhoubných nádorů v České republice. SVOD, 2025. Dostupné na: www.svod.cz
  36. Lambertini M, Peccatori FA, Demeestere I et al. Fertility preservation and post-treatment pregnancies in post-pubertal cancer patients: ESMO clinical practice guidelines†. Ann Oncol 2020; 31: 1664–1678.
  37. Rodriguez-Wallberg KA, Jiang Y, Lekberg T, Nilsson HP. The late effects of cancer treatment on female fertility and the current status of fertility preservation – a narrative review. Life 2023; 13: 1195.
  38. Donnez J. Chemotherapy and decline of the ovarian reserve: How can we explain it and how to prevent it? Fertil Steril 2020; 114: 722–724.
  39. Webber L, Davies M, Anderson R et al. ESHRE Guideline: management of women with premature ovarian insufficiency. Hum Reprod 2016; 31: 926–937.
  40. Massarotti C, Scaruffi P, Lambertini M, et al. Beyond fertility preservation: role of the oncofertility unit in the reproductive and gynecological follow-up of young cancer patients. Hum Reprod 2019; 34: 1462–1469.
  41. Crha I, Huser M, Žáková J. Onkofertilita – perspektivy a komplikace. Onkologie 2018; 12: 25–28.
  42. Anderson RA, Amant F, Braat D et al. ESHRE guideline: female fertility preservation. Hum Reprod Open 2020; 4: hoaa052.
  43. Harris ML, Feyissa TR, Bowden NA et al. Contraceptive use and contraceptive counselling interventions for women of reproductive age with cancer: a systematic review and meta-analysis. BMC Med 2022; 20: 489.
  44. Roth ME, Grimes AC, Reed DR et al. Children’s Oncology Group 2023 blueprint for research: adolescent and young adult oncology. Pediatr Blood Cancer 2023; 70 (Suppl. 6): e30564.
  45. MOÚ představuje nový způsob online komunikace s pacienty. Masarykův onkologický ústav, Brno, 2021. Dostupné na: www.mou.cz/mou-predstavuje-novy-zpusob-online-komunikace-s-pacienty/t1471
  46. Young Adult Program (YAP). Dana-Farber Cancer Institute. Dostupné na: www.dana-farber.org/patient-family/support-services/young-adult-program
  47. Stop Cancer ‘A Spark of Life for the Young’. Dostupné na: www.stop-cancer.co.il/a-spark-of-life-for-the-young
  48. Ben-Aharon I, Goshen-Lago T, Turgeman I et al. Young patients with cancer and a digital social network: the voice beyond the clinic. ESMO Open 2020; 5: e000651.
  49. Prochaska JJ, Coughlin SS, Lyons EJ. Social media and mobile technology for cancer prevention and treatment. Am Soc Clin Oncol Educ Book 2017; 37: 128–137.
  50. Teplinsky E, Ponce SB, Drake EK et al. Online medical misinformation in cancer: distinguishing fact from fiction. JCO Oncol Pract 2022; 18: 584 p589.
  51. Chow R, Drkulec H, Im JHB et al. The use of wearable devices in oncology patients: a systematic review. Oncologist 2024; 29: e419–e430.

   

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Efficiency of health care in the Czech Republic in international comparison 2010–2021
Strategy for prevention of thromboembolic disease in urology
The decision-making on cost-inefficient care
Harm reduction and tobacco smoking
Smoking in cars – unhealthy and hazardous
My patient is taking a statin and is scheduled for surgery
Physical activity in spas – the key to prevention and health promotion
Nutrition and physical activity policies in population-based prevention of non-communicable diseases and their evaluation
Mental health of healthcare professionals in Czechia during and after the COVID-19 pandemic
25 years of ISBER – an overview
Professor Viktor Guttmann – another forgotten laryngologist was born 145 years ago
Přednáškové večery spolku českých lékařů v Praze (březen 2025)
Úvodem
Za profesorem Miloslavem Rakovičem
Article was published in

Journal of Czech Physicians

Issue 7-8
2024 Issue 7-8
Download issue PDF
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#