Adipose tissue in the treatment of androgenic alopecia

Czech version

Authors: Athanasios J. Stefanis
Authors‘ workplace: Dermatovenerologická klinika 3. LF UK a FNKV, Praha
Published in: Čas. Lék. čes. 2023; 162: 9-12
Category: Review Article

Overview

Tuková tkáň je komplexní orgán s různými funkcemi. Působí jako zásobárna energie, tepelný izolant a tlumič nárazů a zastává také roli v endokrinním systému. V posledních letech byl objeven její regenerační a protizánětlivý potenciál.

Za tyto funkce jsou zodpovědné různé typy progenitorových, kmenových a zralých buněk jiných než adipocyty, které se nacházejí v tukové tkáni a souhrnně se označují jako stromální vaskulární frakce.

V retikulární dermis tukové buňky obklopují vlasové folikuly a úzce regulují vlasový cyklus. Intradermální progenitorové adipocyty jsou metabolicky aktivní a vylučují řadu signálních molekul, které jsou zodpovědné za indukci anagenní fáze a růst nových vlasů.

V tomto přehledu se zabýváme účinností kmenových buněk odvozených z tukové tkáně při léčbě alopecie v klinických studiích.

Keywords:

Adipose tissue – alopecia – clinical trial – review – adipose-derived stromal/stem cells – hair loss – stromal vascular fraction

Sources

Avram AS, Avram MM, James WD. Subcutaneous fat in normal and diseased states: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 2005; 53: 671–683.
Gentile P, Orlandi A, Scioli MG et al. Concise review: adipose-derived stromal vascular fraction cells and platelet-rich plasma: basic and clinical implications for tissue engineering therapies in regenerative surgery. Stem Cells Transl Med 2012; 1: 230–236.
Zuk PA, Zhu M, Mizuno H et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7: 211–228.
Bourin P, Bunnell BA, Casteilla L et al. Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 2013; 15: 641–648.
Cohen SR, Hewett S, Ross L et al. Regenerative cells for facial surgery: biofilling and biocontouring. Aesthet Surg J 2017; 37: 16–32.
Rehman J, Traktuev D, Li J et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004; 109: 1292–1298.
Mazo M, Cemborain A, Gavira JJ et al. Adipose stromal vascular fraction improves cardiac function in chronic myocardial infarction through differentiation and paracrine activity. Cell Transplant 2012; 21: 1023–1037.
Rajashekhar G, Ramadan A, Abburi C et al. Regenerative therapeutic potential of adipose stromal cells in early stage diabetic retinopathy. PLoS One 2014; 9: e84671.
Piraccini BM, Alessandrini A. Androgenetic alopecia. G Ital Dermatol Venereol 2014; 149: 15–24.
Varothai S, Bergfeld WF. Androgenetic alopecia: an evidence-based treatment update. Am J Clin Dermatol 2014; 15: 217–230.
Hausman GJ, Martin RJ. The development of adipocytes located around hair follicles in the fetal pig. J Anim Sci 1982; 54: 1286–1296.
Schmidt B, Horsley V. Unravelling hair follicle-adipocyte communication. Exp Dermatol 2012; 21: 827–830.
Aksu AE, Rubin JP, Dudas JR et al. Role of gender and anatomical region on induction of osteogenic differentiation of human adipose-derived stem cells. Ann Plast Surg 2008; 60: 306–322.
Aronowitz JA, Lockhart RA, Hakakian CS. Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. Springerplus 2015; 4: 713.
De Ugarte DA, Morizono K, Elbarbary A et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 2003; 174: 101–109.
Bora P, Majumdar AS. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. Stem Cell Res Ther 2017; 8: 145.
Dykstra JA, Facile T, Patrick RJ et al. Concise review: fat and furious: harnessing the full potential of adipose-derived stromal vascular fraction. Stem Cells Transl Med 2017; 6: 1096–1108.
Markarian CF, Frey GZ, Silveira MD et al. Isolation of adipose-derived stem cells: a comparison among different methods. Biotechnol Lett 2014; 36: 693–702.
Bagno LL, Carvalho D, Mesquita F et al. Sustained IGF-1 secretion by adipose-derived stem cells improves infarcted heart function. Cell Transplant 2016; 25: 1609–1622.
Manferdini C, Maumus M, Gabusi E et al. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E₂. Arthritis Rheum 2013; 65: 1271–1281.
Zimmerlin L, Donnenberg VS, Pfeifer ME et al. Stromal vascular progenitors in adult human adipose tissue. Cytometry A 2010; 77: 22–30.
Rosell A, Morancho A, Navarro-Sobrino M et al. Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice. PLoS One 2013; 8: e73244.
Gokcinar-Yagci B, Uckan-Cetinkaya D, Celebi-Saltik B. Pericytes: properties, functions and applications in tissue engineering. Stem Cell Rev 2015; 11: 549–559.
Farrington-Rock C, Crofts NJ, Doherty MJ et al. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation 2004; 110: 2226–2232.
Hellstrom M, Gerhardt H, Kalen M et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 2001; 153: 543–553.
Dohgu S, Takata F, Yamauchi A et al. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res 2005; 1038: 208–215.
Morris ME, Beare JE, Reed RM et al. Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b⁺ cell-dependent mechanism. Stem Cells Transl Med 2015; 4: 369–380.
Fantin A, Vieira JM, Gestri G et al. Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 2010; 116: 829–840.
Kondělková K, Vokurková D, Krejsek J et al. Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders. Acta Medica (Hradec Kralove) 2010; 53: 73–77.
Stefanis AJ, Groh T, Arenbergerová M et al. Stromal vascular fraction and its role in the management of alopecia: a review. J Clin Aesthet Dermatol 2019;12: 35–44.
Fukuoka H, Suga H, Narita K et al. The latest advance in hair regeneration therapy using proteins secreted by adipose-derived stem cells. Am J Cosmet Surg 2012; 29: 273–282.
Fukuoka H, Suga H. Hair regeneration treatment using adipose-derived stem cell conditioned medium: follow-up with trichograms. Eplasty 2015; 15: e10.
Perez-Meza D, Ziering C, Sforza M et al. Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness. Stem Cells Cloning 2017; 10: 1–10.
Shin H, Ryu HH, Kwon O et al. Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study. Int J Dermatol 2015; 54: 730–735.
Aronowitz JA, Lockhart RA, Birnbaum ZE et al. Stromal vascular fraction enhanced adipose transplantation in hair loss: early experience & Active phase II FDA investigation. Plast Reconstr Surg Global Open 2016; 4: 50.
Öztürk P, Bekerecioglu M. The effect of stromal vascular fraction for patients with androgenetic alopecia. J Turk Acad Dermatol 2020; 14: 107–111.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

ÚVODEM

Current possibilities and risks of donating some tissues, cells, and organs from living donors

Hypercapnic respiratory failure – review

Obesity pharmacotherapy – update 2023

Syndrom křehkosti

Therapeutic effect of lymphography in the postoperative chylothorax – case reports and literature review

Protilátky získané po infekci koronavirem nás dlouhodobě chrání před opakovanou infekcí, pravil už i Lancet

Otakar Tardy, the founder of the ENT department in Litomyšl – commemoration on the 45th anniversary of his death

Zemřel profesor Karel Maršál

Odešel docent Jiří Ramba

Zemřel docent Petr Brandejský

Přednáškové večery Spolku českých lékařů v Praze (duben – květen 2023)