Low levels of vitamin D in population exposed to significant environmental pollution

Czech version

Authors: Josef Richter ¹; Václav Větvička ²; Vlastimil Král ¹; Petr Šíma ³; Iva Stiborová ¹; Stanislava Richterová ⁴; Lucie Rajnohová Dobiášová ¹
Authors‘ workplace: Centrum imunologie a mikrobiologie, Zdravotní ústav se sídlem v Ústí nad Labem ¹; Department of Pathology, University of Louisville, Kentucky, USA ²; Laboratoř imunoterapie, Mikrobiologický ústav AV ČR, Praha ³; Vojenská zdravotní pojišťovna, Ústí nad Labem ⁴
Published in: Čas. Lék. čes. 2022; 161: 314-320
Category: Original Articles

Overview

In recent years, monitoring of vitamin D levels and possible use of supplementation is gaining attention. Numerous studies showed low levels of vitamin D in winter months followed by improvement during summer. These changes are mostly dependent on the level of sun exposure, but also on geographical location, genetic factors, social-economic status, quality of nutrition and environmental pollution.

In this observation we found significant decrease in vitamin D levels in populations exposed to extreme environmental pollution in area of central Europe. This region is known for extreme burden from microparticles originating in chemical industry, surface coal mining and cold-based power stations. Vitamin D levels in all patients was determined by ELISA. Using 540 patients in our department of clinical immunology and allergology we measured the levels of vitamin D in 2016 to 2021 period. In only 4 patients (0.74 %) we found vitamin D levels higher than 30 ng/ml. The curve of observed values does not reflect dependency on sun exposure and does not change during the year.

We discuss the effect of environmental contaminants, lifestyle and economic and social factors. From our observations, we propose to directly supplement population with vitamin D, particularly children and seniors. From our observations, we propose to directly supplement population with vitamin D, particularly children and seniors.

Keywords:

Pollution – health risk – vitamin D – environment

Sources

Amrein K, Scherkl M, Hoffmann M et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr 2020; 74: 1498–1513.
Banihosseini SZ, Baheiraei A, Shirzad N et al. The effect of cigarette smoke on vitamin D level and biochemical parameters of mothers and neonates. J Diabetes Metab Disord 2013; 12: 19.
Barrea L, Savastano S, Di Somma C et al. Low serum vitamin D-status, air pollution and obesity: a dangerous liaison. Rev Endocr Metab Disord 2017; 18: 207–214.
Gani LU, How CH. Vitamin D deficiency. Singapore Med J 2015; 56: 433–437.
Gröber U, Spitz J, Reihrath J et al. Vitamin D: Update 2013. From Rickets prophylaxis to general preventive healthcare. Dermatoendocrinol 2013; 5: 331–347.
Herrick KA, Storandt RJ, Afful J et al. Vitamin D status in the United States, 2011–2014. Am J Clin Nutr 2019; 110: 150–157.
Lips P, Cashman KD, Lamberg-Allardt C et al. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society. Eur J Endocrinol 2019; 180: P23–P54.
Pludowski P, Grant WB, Bhattoa HP et al. Vitamin D status in central Europe. Int J Endocrinol 2014; 2014: 589587.
Rabenberg M, Scheidt-Nave C. Busch MA et al. Vitamin D status among adults in Germany – results from the German Health Interview and Examination Survey for Adults (DESG1). BMC Public Health 2015; 15: 641.
Sakem B, Nock C, Stanga Z et al. Serum concentrations of 25-hydroxyvitamin D and immunoglobulins in an older Swiss cohort: results of the Senior Labor Study. BMC Medicine 2013; 11: 176.
Spiro A, Buttriss JL. Vitamin D: An overview of vitamin D status and intake in Europe. Nutrition Bull 2014; 39: 322–350.
Feizabad E, Hossein-Nezhad A, Maghbooli Z et al. Impact of air pollution on vitam,in D deficiency and bone health in adolescent. Arch Osteoporos 2017; 12: 34.
Sizar O, Khare S, Goyal A et al. Vitamin D Deficiency. StatPearls, Treasure Island, 2022.
Gröber U, Kisters K. Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol 2012; 4: 158–166.
Wacker M, Holick MF. Sunlight and vitamin D. A global perspective for health. Dermatoendocrinol 2013; 5: 51–108.
Papamiditriou DM. The big vitamin D mistake. J Prev Med Public Health 2017; 50: 278–281.
Gröber U, Reichrath J, Hollick F. Live longer with vitamin D? Nutrients 2015; 7: 1871–1880.
Lucas RM, Gorman S, Geldenhuys S et al. Vitamin D and immunity. F1000 Prime Reports 2014; 6: 118.
Prietl B, Treiber G, Pieber TR et al. Vitamin D and immune function. Nutrients 2013; 5: 2502–2521
Sadarangani SP, Ovsyannikova IG, Goergen K et al. Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons. Hum Vaccin Immunother 2016; 12: 691–698.
Gemelli C, Martello, A, Montanari M et al. The orosomucoid 1 protein is involved in the macrophage de-activation process. Exp Cell Res 2013; 319: 3201–3213.
Liu J, Zhang W. The influence of the environment and clothing on human exposure to ultraviolet light. PLoS One, 2015; 10: e0124758.
Godar DE, Pope SJ, Grant WB et al. Solar UV doses of young Americans and vitamin D₃ production. Environment Health Persp 2012; 120: 139–143.
Tourvier M, Deschasaux M, Montourcy M et al. Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, antropometric, and genetic factors. J Invest Dermatol 2015; 135: 378–388.
Richter J, Větvička V, Richterová S et al. Nutrition and immunity during pandemic viral infection. J Nutr Food Sci Tech 2021; 2: 1–6.
Raulio S, Erlund I, Mannisto S et al. Successful nutrition policy: improvement of vitamin D intake and status in Finnish adults over the last decade. Eur J Publ Health 2016; 27: 268–273.
Mousavi SE, Amini H, Heydarpour P et al. Air pollution, environmental chemicals, and smoking may trigger vitamin D deficiency: Evidence and potential mechanisms. Environ Int 2019; 122: 67–90.
Schladitz A, Leníček J, Beneš I et al. Air quality in the German-Czech border region: a focus on harmful fractions of PM and ultrafine particles. Atmospheric Environ 2015; 122: 236–249.
Nwosu BU, Kum-Niji P. Tobacco smoke exposure is an independent predictor of vitamin D deficiency in US children. PLoS One 2018; 13: e0205342.
Svozil V, Richter J, Větvička V. High exposure to pollution requires nutritional improvements in children. Arch Nutrition Food Sci 2020; 1: 30–34.
Migliaccio S, Nisio AD, Mele C et al. Obesity and hypovitaminosis: causality or casualty? Int J Obesity Supplements 2019; 9: 20–31.
Richter J, Větvička V, Král V et al. Vitamin D and COVID-19 infection. Open Biochem J 2023; in press.
Puche RC. On the genetic determinants of hypovitaminosis D. Medicina (Buenos Aires) 2019; 79: 217–224.
Mensink GBM, Fletcher R, Gurinovic M et al. Mapping low intake of micronutrients across Europe. Brit J Nutr 2013; 110: 755–773.
Williams J, Williams C. Responsibility for vitamin D supplementation of elderly care home residents in England: falling through the gap between medicine and food. BMJ Nutr Prev Health 2020; 3: 256–262.
European Commission project information grant 613977 ODIN Project: Food-based solutions for optimal vitamin D nutrition and health through the life cycle. Dostupné na: https://arquivo.pt/wayback/2016041110252/http://www.odin-vitd.eu

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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