Role of microRNAs in the immune system
Authors:
Petra Faltejsková 1; prof. RNDr. Ondřej Slabý, Ph.D. 1,2; Renata Héžová 1; Jaroslav Michálek 1
Authors‘ workplace:
Masarykova univerzita Brno, Univerzitní centrum buněčné imunoterapie
1; Masarykův onkologický ústav Brno, Klinika komplexní onkologické péče
2
Published in:
Čas. Lék. čes. 2010; 149: 10-15
Category:
Review Article
Overview
MicroRNAs are short non-coding RNAs involved in post-trascriptional regulation of gene expression. They can be found in various organisms including animals, plants and viruses and they play a key role in diverse biological processes, such as embryogenesis, differentiation and proliferation of cells, production of cytokines or apoptosis. Since the initial observation, more than 700 microRNAs have been identified in mammalian cells and up to one third of all protein-encoding genes is estimated to be regulated by these small molecules. In order to biological functions of these mRNA targets, it is apparent today, that altered microRNA expression can contribute not only to carcinogenesis but also to serious failure of the immune system. The aim of this review is to summarize the latest findings about the biogenesis and function of microRNAs and to refer on their role in the regulation of ontogenesis of immune system, haematopoiesis, immune responses and viral infections. Possible contribution of microRNAs to the therapy of viral infections is discussed.
Key words:
microRNA, RNA interference, immune system, haematopoiesis, viral infection.
Sources
1. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843–854.
2. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res 2004; 14: 1902–1910.
3. Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415–419.
4. Bohnsack MT, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNAbinding protein that mediates nuclear export of pre-miRNAs. RNA (NY) 2004; 10: 185–191.
5. Meister G, Landthaler M, Patkaniowska A, et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell 2004; 15: 185–197.
6. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science (NY) 2007; 318: 1931–1934.
7. Okamura K, Hagen JW, Duan H, et al. The mirtron pathway generatesmicroRNA class regulatory RNAs in Drosophila. Cell 2007; 130: 89–100.
8. Yang Z, Jakymiw A, Wood MR, et al. GW182 is critical for the stability of GWbodies expressed during the cell cycle and cell proliferation. J Cell Sci 2004; 117: 5567–5578.
9. Li QJ, et al. MiR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 2007; 129, 147–161.
10. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science (NY) 2004; 303: 83–86.
11. Cobb BS, Hertweck A, Smith J, O’Connor E, et al. A role for Dicer in immune regulation. J Exp Med 2006; 203: 2519–2527.
12. Zhou B, Wang S, Mayr C, Bartel DP, Lodish HF. MiR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci USA 2007; 104: 7080–7085.
13. Pillai V, Ortega SB, Wang CK, Karandikar NJ. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007; 123: 18–29.
14. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 2007; 131: 146–159.
15. Ventura A, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 2008; 132: 875–886.
16. Xiao C, Srinivasan L, Balado DP, et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol 2008; 9: 405–414.
17. Fontana L, et al. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 2007; 9: 775–787.
18. Kluiver J, et al. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005; 207” 243–249.
19. Rodriguez A, et al. Requirement of bic/microRNA-155 for normal immune function. Science (NY) 2007; 316: 608–611.
20. Fazi F, et al. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulated human granulopoiesis. Cell 2005; 123: 819–831.
21. Johnnidis JB, et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 2008; 451: 1125–1129.
22. Moschos SA, et al. Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharideinduced inflammation but not in the anti inflammatory action of glucocorticoids. BMC Genomics 2007; 8: 240.
23. Neilson JR, Zheng GX, Burge CB, Sharp PA. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev 2007; 21: 578–589.
24. Taganov KD, et al. NF-kappaB-dependent induction of microRNAmiR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA 2006; 103: 12481–12486.
25. Tili E, et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 2007; 179: 5082–5089.
26. Vigorito E, et al. MicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity 2007; 27: 847–859.
27. Jing Q, et al. Involvement of microRNA in AU-rich elementmediated mRNA instability. Cell 2005; 120: 623–634.
28. Lecellier CH, Dunoyer P, Arar K, et al. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557–560.
29. Pedersen IM, Cheby G, Wieland S, et al. Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 2007; 449: 919–922.
30. Pfeffer S, et al. Identification of microRNAs of the herpesvirus family. Nat. Methods 2005; 2: 269–276.
31. Stern-Ginossar N, et al. Host immune system gene targeting by a viral miRNA. Science 2007; 317: 376–381.
32. Gupta A, et al. Anti-apoptotic function of a microRNA encoded by the HSV-1 latencyassociated transcript. Nature 2006; 442: 82–85.
33. Triboulet R, et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 2007; 315: 1579–1582.
34. Asirvatham AJ, et al. MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol. Immunol. 2008; 45: 1995–2006.
35. Krützfeldt J, et al. Silencing of microRNAs in vivo with antagomirs. Nature 2005; 438: 685–689.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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