Adverse effects of immunoglobulin therapy
Authors:
Iva Šutová; Zita Chovancová; Jiří Litzman
Authors‘ workplace:
Ústav klinické imunologie a alergologie LF MU a FN u sv. Anny v Brně
Published in:
Vnitř Lék 2019; 65(2): 131-135
Category:
Overview
Immunoglobulin products contain specific antibodies in IgG class which are directed against wide range of pathogens. These products are obtained from plasma of healthy donors. Immunoglobulin derivates can be administrated by intravenous or subcutaneous route in substitution or immunomodulation indications. The administration can be accompanied by a risk of adverse events. The most common are pyretic reactions, chills, headache, nausea, malaise and muscle pain, nevertheless also severe systemic reactions can occur. Almost one third of the reactions appear during the first administration. The number and severity of reactions depends on administered dose, speed and the application way. Pre-existing comorbidities of the patients and presence of acute infection are also an important risk factors for adverse reactions. Therapy of side effects is mostly symptomatic.
Keywords:
Adverse events – anaphylaxis – intravenous immunoglobulins – subcutaneous immunoglobulins
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Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2019 Issue 2
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