Defensive and damaging inflammation: basic characteristics
Authors:
Jan Krejsek
Authors‘ workplace:
Ústav klinické imunologie a alergologie LF UK a FN Hradec Králové
Published in:
Vnitř Lék 2019; 65(2): 76-80
Category:
Overview
Immune system is the integral part of the complex body response, inflammation, which is raised either by the exposure to external signals, predominantly pathogens or by damage of own structures. Predominantly innate immunity is equiped by the receptors recognizing pathogenic PAMPs or signals of own damage DAMPs. The inflammatory response is reflecting the actual demand of our body. The potential of the inflammatory response is so powerful that its intensity and extent have to be carefully regulated on many levels.
Keywords:
Homeostasis – inflammation – PRR receptors
Sources
- Krejsek J, Andrýs C, Krčmová I. Imunologie člověka. Garamon: Hradec Králové 2016. ISBN 978–80–86472–74–4.
- Matsumoto M, Takeda Y, Tatematsu M et al. Toll-like receptor 3 signal in dendritic cells benefits cancer immunotherapy. Front Immunol 2017; 8: 1897. Dostupné z DOI: <http://dx.doi.org/10.3389/fimmu.2017.01897>.
- Oczypok EA, Perkins TN, Oury TD. All the „RAGE“ in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr Respir Rev 2017; 23: 40–49. Dostupné z DOI: <http://dx.doi.org/10.1016/j.prrv.2017.03.012>.
- Dominguez-Martinez DA, Nunez-Avellaneda D, Castanon-Sanchez CA et al. NOD2: Activation during bacterial and viral infections, polymorphisms and potential as therapeutic target. Rev Invest Clin 2018; 70(1): 18–28. Dostupné z DOI: <http://dx.doi.org/10.24875/RIC.17002327>.
- Coutermarsh-Ott S, Eden K, Allen IC. Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure. J Gen Virol 2016; 97(4): 825–838. Dostupné z DOI: <http://dx.doi.org/10.1099/jgv.0.000401>.
- Cronkite DA, Strutt TM. The regulation of inflammation by innate and adaptive lymphocytes. J Immunol Res 2018:1467538. Dostupné z DOI: <http://dx.doi.org/10.1155/2018/1467538>.
- Domogalla MP, Rostan PV, Raker VK et al. Tolerance through education: how tolerogenic dendritic cells shape immunity. Front Immunol 2017; 8: 1764. Dostupné z DOI: <http://dx.doi.org/10.3389/fimmu.2017.01764>.
- Cruz MS, Diamond A, Russell A et al. Human αβ and γδ T cells in skin immunity and disease. Frontiers Immunol 2018; 9: 1304. Dostupné z DOI: <http://dx.doi.org/10.3389/fimmu.2018.01304>.
- Kuwabara T, Ishikawa F, Kondo M et al. The role of IL-17 and related cytokines in inflammatory autoimmune diseases. Mediators Inflamm 2017: 3908061. Dostupné z DOI: http://dx.doi.org/10.1155/2017/3908061
- Timmermans K, Kox M, Scheffer GJ et al. Danger in the intensive care unit: DAMPs in critically ill patients. Shock 2016; 45(2): 108–116. Dostupné z DOI: <http://dx.doi.org/10.1097/SHK.0000000000000506>.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2019 Issue 2
Most read in this issue
- Anaphylactic symptoms and anaphylactic shock
- Adverse effects of immunoglobulin therapy
- Current trends in immunosuppressive treatment
- Primary immunodeficiencies in adults