Anaphylactic symptoms and anaphylactic shock

Czech version

Authors: Irena Krčmová; Jakub Novosad
Authors‘ workplace: Ústav klinické imunologie a alergologie LF UK a FN Hradec Králové
Published in: Vnitř Lék 2019; 65(2): 149-156
Category:

Overview

Anaphylactic symptoms and anaphylactic shock are serious, rapidly developing and potentially fatal systemic reactions occurring after contact with the trigger, followed by release of a number of substances that affect vascular permeability, smooth muscle tone of blood vessels and bronchi with activation of the systemic inflammatory cascade. From a pathophysiological point of view, it can be an IgE-mediated immune response followed by massive release of biologically active mediators from mast cells and basophils (IgE dependent). If the mastocyt/basophil is degranulated via a direct IgE-free pathway, it is non-allergic (non-IgE dependent, anaphylactoid anaphylaxis). The diagnosis of anaphylaxis is determined on the basis of clinical criteria, taking into account the need to initiate therapy in a life-threatening condition without delay. Adrenaline is the first-line drug in the treatment of anaphylaxis and there is no contraindication to its use. Early provision of venous intake is essential for the patient to develop hypotension.

Keywords:

Adverse events – IgE dependent anaphylaxis – non IgE dependent anaphylaxis – management of anaphylaxis

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Article was published in

Internal Medicine

2019 Issue 2