Acute hyperglycemia and reperfusion therapy in stroke patients

Czech version

Authors: D. Krajíčková
Authors‘ workplace: Neurologická klinika Lékařské fakulty UK a FN Hradec Králové, přednosta MU Dr. Radomír Taláb, CSc.
Published in: Vnitř Lék 2010; 56(4): 295-300
Category: 11th National Diabetes Symposium "Diabetes and Angiology", Hradec Kralove, 5 to 6 June 2009

Overview

Current acute therapies for ischemic stroke are limited. Only a small proportion of stroke patients are eligible to receive reperfusion therapy. Acute hyperglycemia has a deleterious effect in stroke patients by accelerating ischemic brain damage. The complex relationship between hyperglycemia and stroke is discussed. In tPA‑treated patients, the acute but not chronic hyperglycemic state may hamper fibrinolytic process, delaying reperfusion of ischemic penumbra. Early measures to reduce hyperglycemia may favor early recanalization.

Key words:
hyperglycemia – reperfusion therapy – acute ischemic stroke

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