Activity of the hypothalamic – pituitary – adrenal axis in patients with rheumatoid arthritis

Czech version

Authors: R. Imrich
Authors‘ workplace: Molekulárno- medicínske centrum SAV, Ústav experimentálnej endokrinológie SAV Bratislava, Slovenská republika, riaditeľ prof. MU Dr. Iwar Klimeš, DrSc.
Published in: Vnitř Lék 2010; 56(12): 1271-1273
Category: Celebration

Overview

The controlled data accumulated so far support only subtle alterations in hypothalamic– pituitary‑adrenal (HPA) axis function in rheumatoid arthritis (RA), mainly at the adrenal level, and particularly in a subset of premenopausal onset women. Consequences of the subtle HPA alterations in RA for the disease development remain unclear. From a broader perspective, the unresponsiveness of the HPA axis to chronic inflammation in RA can be simply considered an ongoing adaptation to chronic disease.

Key words:
hypothalamic-pituitary-adrenal axis – rheumatoid arthritis – chronic inflammation

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