#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Recent Trends in the Pathophysiology of Migraine


Authors: R. Kotas
Authors‘ workplace: Neurologická klinika FN a LF UK, Plzeň, přednosta prof. MUDr. Z. Ambler, DrSc.
Published in: Prakt. Lék. 1999; (9): 498-500
Category:

Overview

This review describes the etiopathogenesis of migraine. The basis for the development ofa migrainous attack is a primary neuronal dysfunction similar to experimental Leao’s sprea-ding depression. Neuronal depolarization followed by suppression of neuronal activity spreadsin a wave across the surface of the brain, accompanied by cerebral blood flow changes. Theseare detectable in migraine with aura by SPECT (single photon emission computed tomography)or in migraine without aura by PET (positron emission tomography). Consequently activationof the trigeminovascular system occurs and the neurogenic sterile inflammation in the vesselwall of intracranial arteries develops which is responsible for the painful phase.

Key words:
Leao’s spreading depression - trigeminovascular system - sterile perivascularinflammation.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
General practitioner for children and adolescents General practitioner for adults
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#