Pancreatic cancer surveillance in high-risk individuals Position statement of professional societies

Czech version

Authors: P. Vaněk ¹; T. Andrašina ²; V. Bitnerová ³; J. Ehrmann ⁴; Přemysl Falt ¹; R. Havlík ⁵; M. Heřman ⁶; T. Hucl ⁷; M. Janíková ³; Z. Kala ⁸; I. Kiss ⁹; D. Kloss ⁵; R. Kovář ⁶; Jan Křivinka ¹; L. Kunovsky ¹; D. Kurfúrstová ⁴; M. Loveček ⁵; P. Mačinga ⁷; B. Melichar ¹⁰; B. Mohelníková Duchoňová ¹⁰; L. Petruželka ¹¹; M. Procházka ³; R. Repák ¹²; P. Skalický ⁵; D. Skanderová ⁴; P. Slodička ¹; Š. Suchánek ¹³; Š. Šembera ¹²; H. Švébišová ¹⁰; I. Tachecí ¹²; J. Tesaříková ⁵; T. Tichý ¹; R. Vrtěl ³; P. Vítek ¹⁴; M. Zavoral ¹³; V. Zoundjiekpon ¹; O. Urban ¹
Authors‘ workplace: II. interní klinika – gastroenterologická a geriatrická LF UP a FN Olomouc ¹; Klinika radiologie a nukleární medicíny LF MU a FN Brno ²; Ústav lékařské genetiky LF UP a FN Olomouc ³; Ústav klinické a molekulární patologie LF UP a FN Olomouc ⁴; I. chirurgická klinika LF UP a FN Olomouc ⁵; Radiologická klinika LF UP a FN Olomouc ⁶; Klinika hepatogastroenterologie IKEM, Praha ⁷; Chirugická klinika LF MU a FN Brno ⁸; Klinika komplexní onkologické péče MOÚ, Brno ⁹; Onkologická klinika LF UP a FN Olomouc ¹⁰; Onkologická klinika 1. LF UK a VFN v Praze ¹¹; II. interní gastroenterologická klinika LF UK a FN v Hradci Králové ¹²; Ústav gastrointestinální onkologie a Interní klinika 1. LF UK a ÚVN Praha ¹³; Interní oddělení, Nemocnice ve Frýdku-Místku, p. o. ¹⁴
Published in: Gastroent Hepatol 2023; 77(6): 529-538
Category:
doi: https://doi.org/10.48095/ccgh2023529

Overview

Stanovisko podporují tyto odborné společnosti ČLS JEP

Česká gastroenterologická společnost (ČGS)
Společnost pro gastrointestinální onkologii (SGO)
Česká chirurgická společnost (ČCHS)
Česká onkologická společnost (ČOS)
Český pankreatologický klub (ČPK)

Terminologická poznámka

Pojem surveillance (dohled) je v textu použit podle terminologického standardu používaného v České republice. V tomto smyslu nahrazuje termín screening (osob ve vysokém riziku), který se vyskytuje v některých anglických textech.

Preambule

Karcinom pankreatu (PC – pancreatic cancer) je závažné onemocnění s narůstající incidencí a vysokou letalitou. V posledních letech byly definovány skupiny osob se zvýšeným rizikem onemocnění a dále byly publikovány výsledky studií z expertních center, ukazující prodloužené dožití nemocných, u nichž byl PC diagnostikován v asymptomatickém stadiu. S vědomím rychlého vývoje znalostí v této oblasti si autoři textu kladou za cíl shrnout současnou úroveň poznání, definovat principy surveillance PC a přispět ke zvýšení úrovně péče o ohrožené osoby v České republice.

Souhrn výstupů

V rámci surveillance PC doporučujeme:

1. Neprovádět screening u osob s průměrným rizikem.
2. Dispenzarizovat osoby s vysokým rizikem.
3. Zařazovat pouze osoby poučené o výhodách a limitech surveillance, které jsou současně potenciálními kandidáty chirurgické léčby.
4. Používat metody EUS a MR/MRCP v jednoročních intervalech.
5. Za klinické cíle považovat prekancerózní léze, resekabilní a hraničně resekabilní PC (T1–3 a/nebo N0–2).
6. Vést registr zařazených osob.

Keywords:

pancreatic cancer – screening – surveillance – high-risk individuals

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