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Fecal bacteriotherapy for the treatment of recurrent Clostridium difficile colitis used in the Clinic of Infectious Diseases of the University Hospital Brno in 2010–2014 – a prospective study


Authors: P. Polák 1,2,3;  M. Freibergerová 1;  P. Husa 1,2;  J. Juránková 3,4;  R. Svačinka 2;  L. Mikešová 2;  H. Kocourková 2;  M. Mihalčin 1,2;  R. Skalická 2;  R. Stebel 1,2;  M. Porubčanová 1,2
Authors‘ workplace: Lékařská fakulta Masarykovy univerzity Brno 1;  Klinika infekčních chorob, Fakultní nemocnice Brno 2;  Oddělení klinické hematologie, Fakultní nemocnice Brno 3;  Oddělení klinické mikrobiologie, Fakultní nemocnice Brno 4;  Katedra laboratorních metod, Lékařská fakulta Masarykovy univerzity Brno 5
Published in: Epidemiol. Mikrobiol. Imunol. 64, 2015, č. 4, s. 232-235
Category: Original Papers

Overview

Introduction:
The aim of the study is to assess the efficacy of fecal bacteriotherapy in the treatment of Clostridium difficile colitis.

Materials and methods:
A prospective study of fecal bacteriotherapy in 80 adult patients hospitalized in the Clinic of Infectious Diseases, University Hospital Brno between 1 January 2010 and 31 December 2014.

Results:
During the study period, 80 patients were treated with fecal bacteriotherapy. The majority of the study group received fecal bacteriotherapy via a nasojejunal tube (n=78) and two patients via a rectal enema. Six patients were instilled with 20 g of feces, with a success rate of 50 %. The outcomes of nine patients were unevaluable. In the rest of 65 patients, the success rate with 40 g of feces was 83.1 %. There were no severe adverse events or mortality associated with fecal bacteriotherapy.

Conclusions:
Fecal bacteriotherapy is a safe and effective treatment modality in Clostridium difficile colitis.

Keywords:
Clostridium difficile colitis – recurrence – fecal bacteriotherapy


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