Allergy to beta-lactam antibiotics in children
Authors:
J. Paukert; E. Kopelentová; L. Dvořáková; M. Králová; M. Charvátová; M. Paukertová; Š. Dobiášová
Authors‘ workplace:
Ambulance alergologie a klinické imunologie, Dětské oddělení, Oblastní nemocnice Kolín, a. s.
primář MUDr. R. Hrdlička
Published in:
Čes-slov Pediat 2015; 70 (1): 9-13.
Category:
Original Papers
Overview
Allergy to beta-lactam antibiotics is frequently reported in the medical history. Diagnosis is usually based on clinical symptoms. Evaluation by skin tests, laboratory tests and a challenge test in selected cases helps to determine the correct diagnosis of a drug allergy.
We evaluated 173 patients with suspected beta-lactam hypersensitivity between years 2008–2014. Allergy to beta-lactam antibiotics was confirmed in only 16 (10%) patients. Out of those 3 (19%) experienced anaphylaxis, 5 (31%) early skin reaction and 8 (50%) delayed skin reaction. The diagnosis was confirmed by laboratory tests in 2 cases (13%), skin testing in 6 cases (37%) and a challenge test in 8 cases (50%). After completion of allergologic evaluation the suspected antibiotic was released for further use in 90%. Drug provocation testing/challenge testing is a safe and integral part of the evaluation.
Key words:
penicillin, beta-lactam antibiotics, antibiotic allergy, provocation testing, skin testing
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Labels
Neonatology Paediatrics General practitioner for children and adolescentsArticle was published in
Czech-Slovak Pediatrics
2015 Issue 1
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