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Thromboembolism by Children in Relation with Factor V Leiden Mutation and Oral Contraception


Authors: V. Vávra 1;  P. Smíšek 1;  P. Sedláček 1;  V. Komrska 1;  I. Hadačová 3;  K. Mužíková 2;  K. Zdráhalová 1;  J. Starý 1
Authors‘ workplace: II. dětská klinika 2. LF UK a FN Motol, Praha1 přednosta prof. MUDr. J. Vavřinec, DrSc. Laboratoř molekulární genetiky 2. LF UK, Praha2 vedoucí doc. MUDr. J. Trka, PhD. Hematologické oddělení FN Motol, Praha3 primářka MUDr. I. Hochová
Published in: Čes-slov Pediat 2004; (4): 192-194.
Category:

Overview

Genetic base for Leiden mutation of F.V (FVL) is a point mutation (1691 G to A) on a gene for F.V with anautosomal dominant heredity. There is 5%prevalence of FVL mutation in caucassian population. In a populationof European women are there 80% of oral contraceptions users. The risk of deep vein thrombosis (DVT) amongthe women-FVL carriers is 30 times higher then in common population. The oral contraception ranks among riskfactors for DVP. The effect of the thrombophilic risk factors is additive. In this article 2 cases of young girls withDVP and early use of OC are described. In both cases has developed ileofemoral thrombosis with embolisation tolungs shortly after OC was applicated. Both patients were cured with low-molecular heparin and later warfarinized.After this therapy the deep veins were partially recanalised. The cause of this thrombophilic state was FVLin homozygous constitution potentionated with OC.

Key words:
Leiden mutation of F.V, oral contraception, deep veins thrombosis

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Labels
Neonatology Paediatrics General practitioner for children and adolescents
Topics Journals
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