Light Acne Treatment

Czech version

Authors: M. Sochor ¹; J. Buchvald ¹; R. Sochorová ²; M. Šimaljaková ¹
Authors‘ workplace: Dermatovenerologická klinika LF UK a FNsP, Bratislava prednostka prof. MUDr. Mária Šimaljaková, PhD. ¹; Lekárska kozmetika LifeStyle, Bratislava ²
Published in: Čes-slov Derm, 85, 2010, No. 6, p. 325-330
Category: Pharmacologyand Therapy, Clinical Trials

Overview

A great increased number of light-based therapies of acne have arisen in the past decade. High pressure gas tubes, fluorescent tubes and LEDs (Light Emitting Diodes) are the most common light sources. The l 415 ± 10 nm wave length is the mostly used one, because it is well absorbed in the protoporphyrin IX (PpIX) in Propionibacterium acnes (P. acnes). Light-based PpIX disintegration leads into production of oxygen radicals that destroy the P. acnes. Recently, an evidence of the anti-inflammatory properties of blue light is becoming more recognized. The red light (630 nm) is also used in acne treatment. Better results are achieved when the phototherapy is combined with other treatment modalities (e.i. topical keratolytics). Relapses occuring shortly after finishing treatment series are the main drawback of optical treatment methods.

Key words:
acne – phototherapy – blue light – protoporhyrin IX (PpIX) – 415 nm

Sources

1. ALEXIADES-ARMENAKAS, M. Long-pulsed dye laser--mediated photodynamic therapy combined with topical therapy for mild to severe comedonal, inflammatory, or cystic acne. J Drugs Dermatol, 2006, 5, p. 45–55.

2. BAUGH, W., KUCABA, W. Nonablative phototherapy for acne vulgaris using the KTP 532 nm laser. Dermatol Surg, 2005, 31, p. 1290–6.

3. Bornmer, S. Hautuntersuchungen im gefiteren Quartzlicht. Klin Wochenschr., 1927, 6, s. 1142–1144.

4. BOWES, I., MANSTEIN, D., ANDERSON, R. Effects of 532 nm KTP laser on acne and sebaceous glands. Lasers Med Sci, 2003, 18, S6–S7.

5. Cornelius, C. E., Ludwig, G. D. Red fluorescence of comedones: production of porphyrins by Corynebacterium acnes. J Invest Dermatol, 1967, 49, p. 368–370.

6. DIERICKX, C. C. Treatment o facne vulgaris with a variable filtration IPL system. Lasers Surg Med Supplement, 2004, 16, 22.

7. GOLD, M., BRADSHAW, V., BORING, M. et al. The use of a novel intense pulsed light and heat source and ALA-PDT in the treatment of moderate to severe inflammatory acne vulgaris. J Drugs Dermatol, 2004, 3 (6 suppl), p. 15–19.

8. Goldberg, D. J., Russell, B. A. Combination blue (415nm) and red (633nm) LED phototherapy in the treatment of mild to severe acne vulgaris. J Cosmet Laser Ther., 2006, 8, s. 71–75.

9. GOLDMAN, M., BOYCE, S. A single-center study of aminolevulinic acid and 417 nm photodynamic therapy in the treatment of moderate to severe acne vulgaris. J Drugs Dermatol, 2003, 2, p. 393–396.

10. HONGCHARU, W., TAYLOR, C., CHANG, Y. et al. Topical ALA photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol, 2000, 115, p. 183–192.

11. JIH, M. H., FRIEDMAN, P. M., GOLDBERG, L. H. et al. The 1450-nm diode laser for facial inflammatory acne vulgaris: dose–response and 12-month follow-up study. J Am Acad Dermatol, 2006, 55, p. 80–87.

12. Johnsson, A., Kjeldstad, B., Melo, T. B. Fluorescence from pilosebaceous follicles. Arch Dermatol Res., 1987, 279, p. 190–193.

13. KARSAI, S., SCHMITT, L., RAULIN, C. The pulsed-dye laser as an adjuvant treatment modality in acne vulgaris: a randomized controlled single-blinded trial. Br J Dermatol, published online 15 Apr 2010.

14. KAWADA, A., ARAGANE, Y. et al. Acne phototherapy with a high-intensity, enhanced, narrow-band, blue light source: an open study and in vitro investigation. J Dermatol Sci., 2002, 30, p. 129–135.

15. KENNEDY, J., POTTIER, R., PROSS, D. Photodynamic therapy with endogenous protoporphyrin IX, basic principles and present clinical experience. J Photochem Photobiol B, 1990, 6, p. 143–148.

16. KJELDSTAD, B., JOHNSSON, A. An action spectrum for blue and near ultraviolet inactivation of Propionibacterium acnes; with emphasis on a possible porphyrin photosensitization. Photochem Photobiol., 1986, 43, p. 67–70.

17. KÖNIG, K., RUCK, A., SCHENCKENBURGER, H. Fluorescence detection and photodynamic activity of endogenous porphyrins in human skin. Opt. Engineering, 1992, 31, p. 1470–1474.

18. LLOYD, J., MIRKOV, M. Selective photothermolysis of the sebaceous glands for acne treatment. Lasers Surg Med, 2002, 31, p. 115–120.

19. Meffert, H., Gaunitz, K., Gutewort, T., Amlong, U. J. Aknetherapie mit sichtbarem Licht: Verkuerzung der Bestrahlungszeit durch Verwendung eines Hochdruckstrahlers vom Blaulichttyp. Dermatol Monatsschr., 1990, 176, s. 597–603.

20. PAITHANKAR, D., ROSS, E., SALEH, E., BLAIR, M., GRAHAM, A. Acne treatment with a 1,450nm wavelength laser and cryogen spray cooling. Lasers Surg Med, 2002, 31, p. 106–114.

21. PAPAGEORGIOU, P., KATSAMBAS, A., CHU, A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol, 2000, 142, p. 973–978.

22. PAPAGEORGIOU, P., KATSAMBAS, A., CHU, A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol, 2000, 142, p. 973–978.

23. ROSS, E. V. Optical treatments for acne. Dermatologic therapy, 2005, 18, p. 253–266.

24. SEATON, E., CHARAKIDA, A., MOUSER, P. et al. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. Lancet, 2003, 362, p. 1347–1352.

25. SHNITKIND, E., YAPING, E., GREEN, S. et al. Anti- inflammatory properties of narrow-band blue light. J Drugs Dermatol, 2006, 5, p. 605–610.

26. SOCHOR, M., SOCHOROVA, R., BUCHVALD, J. Blue light phototherapy for the treatment of acne. In Abstract. 21st World Congress of Dermatology, Buenos Aires, 2007.

27. TREMBLAY, J., SIRE, D. et al. Light-emitting diode 415nm in the treatment of inflammatory acne: an open- -label, multicentric, pilot investigation. J Cosmet Laser Ther., 2006, 8, p. 31–33.

28. TZUNG, T. Y., WU, K. H., HUANG, M. L. Blue light phototherapy in the treatment of acne. Photodermatol Photoimmunol Photomed., 2004, 20, p. 266–269.

29. WIEGELL, S. R., WULF, H. C. Photodynamic therapy o facne vulgaris using methyl aminolevulinate: a blinded, randomized, controlled trial. Br J Dermatol, 2006, 154, p. 969–76.

Labels

Dermatology & STDs Paediatric dermatology & STDs

Darier Disease and Related Disorders

Dermatitis Family Impact Questionnaire – Czech Validation

Confluent and Reticulated Papillomatosis of Gougerot and Carteaud

Cutis Marmorata Teleangiectatica Congenita

Article was published in

Czech-Slovak Dermatology

2010 Issue 6