Pohľad na klasifi káciu a manažment endometriálneho karcinómu v kontexte molekulárnych subtypov
Authors:
Zuzana Ballová; Petra Gašparová; M. Sitáš; Erik Dosedla
Authors‘ workplace:
Department of Gynaecology and Obstetrics, Faculty of Medicine, University P. J. Safarik in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic
Published in:
Ceska Gynekol 2024; 89(2): 128-132
Category:
doi:
https://doi.org/10.48095/cccg2024128
Overview
Karcinóm endometria je najčastejším gynekologickým karcinómom a druhým najčastejším ženským zhubným nádorom v rozvinutom svete. Zvyčajne sa diagnostikovaný u žien po menopauze s typickým klinickým obrazom abnormálneho krvácania z maternice. V minulosti sa na základe histologického hodnotenia zvažovali iba dva typy. Endometriálny karcinóm je však klinicky heterogénne ochorenie a je čoraz jasnejšie, že táto heterogenita môže byť hybnou silou pri určení rôznorodosti na základe molekulárnych zmien. The Cancer Genome Atlas klasifikačný systémy zlepšil diagnostiku, stratifikáciu rizika a manažment endometriálneho karcinómu popisom štyroch molekulárnych podskupín s rôznou mutačnou záťažou a zmenami v počte kópií.
Klíčová slova:
p53 – endometriálny karcinóm – molekulárna klasifikácia – POLE mutácia – The Cancer Genome Atlas Research Network – hysterektómia – cielená terapia – mismatch-repair
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ORCID authors
Z. Ballová 0000-0002-0605-948X
P. Gašparová 0000-0002-6354-6911
M. Sitáš 0000-0002-7273-1051
E. Dosedla 0000-0001-8319-9008
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
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