Various approaches of endometrial preparation for frozen-thawed embryo transfer

Czech version

Authors: J. Vodička ¹; M. Dvořan ¹; K. Smékalová ¹; Ľ. Michnová ²; P. Hejtmánek ¹; K. Lehnertová ¹; J. Dostál ¹; M. Pešková ¹; M. Annenková ¹; R. Pilka ¹
Authors‘ workplace: Porodnicko-gynekologická klinika LF UP a FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ¹; IVF Clinic, Olomouc, vedoucí lékař MUDr. Š. Machač, Ph. D. ²
Published in: Ceska Gynekol 2018; 83(1): 24-28

Overview

Objective:
Various approaches of endometrial preparation for frozen-thawed embryo transfer.

Design:
Retrospective analysis.

Setting:
Department of Obstetric and Gyneacology, Faculty of Medicine, Palacky University, University Hospital Olomouc.

Methods:
Effectivity of frozen-thawed embryo transfers was carried out between January and August 2017 in the IVF unit at the University Hospital Olomouc. Results were compared among groups A, B, C with various approaches of endometrial preparation. Group A – natural ovulating cycle, group B – artificial cycle with oral estrogen, vaginal gestagen and group C – artificial cycle with transdermal estrogen and vaginal gestagen. One blastocyst (two blastocyst in five cycles) was transferred on day 6 post ovulation (group A) or after 6 days of using gestagens (group B, C).

Results:
The highest pregnancy rate was observed in group C (56%), similar pregnancy rate was found in group B (52%) and the lowest was seen in group A (22%). All pregnancies in group A continued over 12 weeks, in group B continued 57 percent and in group C continued 56 percent of pregnancies.

Conclusion:
Frozen-thawed embryotransfers in natural cycles are highly time-consuming. Our study has demonstrated the lowest effectivity of frozen-embryotransfer in natural cycles. Artificial cycles managed by oral or transdermal form of estrogen have shown better results.

Keywords:
frozen-thawed embryotransfer, natural cycle, artificial cycle, pregnancy rate

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