Urinary incontinence induced by the antidepressants – case report

Czech version

Authors: J. Krhut ^1,2; M. Gärtner ³
Authors‘ workplace: Urologické oddělení FN, Ostrava, primář doc. MUDr. J. Krhut, Ph. D. ¹; Katedra chirurgických oborů LF OU, Ostrava, přednosta doc. MUDr. P. Zonča, Ph. D., FRCS ²; Gynekologicko-porodnická klinika FN, Ostrava, přednosta doc. MUDr. V. Unzeitig, CSc. ³
Published in: Ceska Gynekol 2015; 80(1): 65-68

Overview

Aim:
Case study of the patient with urinary incontinence induced by the antidepressant mirtazapin and the review of the related literature.

Design:
Case report.

Setting:
Department of Urology, University Hospital Ostrava-Poruba.

Case report:
A case of 55-years old patiens, who was reffered to the surgical treatment of the urinary incontinence. We found a major discrepancies during the evaluation that led us to suspect that this is not a common uncomplicated case of stress urinary incontinence. Based on the detailed history we identified the antidepressant mirtazapine as a likely causal factor. After discontinuing mirtazapin patient has achieved full control of the continence.

Conclusion:
Given that antidepressants affects adrenergic and dopaminergic regulatory mechanisms in the central nervous system, they may affect the lower urinary tract function. This work presents a case report where the disclosure of the less common cause of incontinence saved the patientoriginally proposed surgical treatment and allowed the effective restoration of the continence. We emphasize the need to consider the potential interaction of antidepressants with lower urinary tract function in daily practice.

Keywords:
urinary incontinence, antidepressants, serotonin, noradrenalin, mirtazapine

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