Recurrent implantation failure and thrombophilia

Czech version

Authors: V. Lattová ¹; J. Dostál ¹; M. Pešková ¹; A. Sobek jr. ²; M. Procházka ^1,3
Authors‘ workplace: Porodnicko-gynekologická klinika FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D. ¹; Fertimed, Olomouc, doc. A. Sobek ²; Ústav porodní asistence, Fakulta zdravotnických věd LF UP, Olomouc, přednosta doc. MUDr. M. Procházka, Ph. D. ³
Published in: Ceska Gynekol 2015; 80(1): 5-10

Overview

Objective:
Bring a comprehensive overview of the available knowledge about the importance of thrombophilic mutations in patients with recurrent implantation failure and summary of therapeutic options.

Design:
Overview study.

Setting:
Department of Obstetric and Gynecology, University Hospital Olomouc.

Methods:
Analysis of literary sources and databases Ovid, Medline.

Conclusion:
Failure of implantation in the context of assisted reproduction is associated with impaired endometrial receptivity. In women with normal anatomy may affect the implantation of embryos during stimulation hormonal changes, immunological factors or thrombophilic mutations. Recurrent implantation failure patients should be tested for the presence of thrombophilic mutations. Subsequently, these patients should be individually consulted and low molecular weight heparin should be used only in indicated cases. According to the available data treatment is recommended only in patients with known acquired or inherited thrombophilic disorder.

Keywords:
IVF, thrombophilia, recurrent implantation failure

Sources

1. Bartocci, A., Pollard, JW., Stanley, ER. Regulation of CSF-1 during pregnancy. J Exp Med, 1986, 164, p. 956–961.

2. Bellver, SR., Soares, C., Alvarez, E., et al. The role of thrombophilia and thyroid autominunity in unexplained infertility, implantation failure and recurrent spontaneus abortion. Hum Reprod, 2008, 23, p. 278–284.

3. Bischof, P., Friedli, E., Martelli, M., et al. Expression of extracellular matrix-degrading metalloproteinases by culture human cytotrophoblast cell: effects of cell adhesion and immuno purification. Am J Obstet Gynecol, 1991, 165, p. 1791–1801.

4. Damsky, CH., Librach, C., Lim, KH., et al. Integrin switching regulates normal trophoblast invasion. Development, 1994, 120, p. 3657–3666.

5. Das, SK., Wang, X., Paria, BC., et al. Heparin binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development, 1994, 120, p. 1071–1083.

6. Di Nisio, M., Rutjes, AW., Ferrante, N. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and metaanalysis. Blood, 2011, 118, p. 2670–2678.

7. Edwards, RG. Implantation, interception and contraception. Hum Reprod, 1994, 9, p. 985–995.

8. Enders, AC. Current topic: structural responses of the primate endometrium to implantation. Placenta, 1991, 12, p. 309–325.

9. Fatemi, HM., Popovic-Todorovic, B. Implantation in assisted reproduction: a look et endometrial receptivity. Reprod Biomed online, 2013, 27, p. 530–538.

10. Fatini, C., et al. Unexplained infertility: Association with inherited thrombophilia. Tromb Res, 2012, 129, p. 185–188.

11. Grandone, E., Colaizzo, D., Lo Bue, A. Inherited thrombophilia and in vitro fertilization implantation failure. Fertil Steril, 2001, 76, p. 201–202.

12. Hey, NA., Graham, RA., Seif, MW., et al. The polymorphic epithelial mucin MUC 1 in human endometrium is regulated with maximal expression in the implantation phase. J Clin Endocrinol Metab, 1994, 78, p. 337–342.

13. Charnock-Jones, DS., Kaspar, P., Brunet, LJ., et al. Leukaemia inhibitory factor mRNA concentration peaks in human endometrium at the time of implantation and the blastocyst contains mRNA for the receptor at this time. J Reprod Fertil, 1994, 101, p. 421–426.

14. Khalaf, Y., El-Toukhy, T., Coomarasamy, A. Selective single blastocyst transfer reduces the multiple pregnancy rate and increases pregnancy rates: a pre- and postintervention study. BJOG, 2008, 115, p. 385–390.

15. Kliman, HJ., Feinberg, RJ., Schwartz, LB., et al. A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle – dependent localization in human endometrium. Am J Pathol, 1995, 146, p. 166–181.

16. Lédeé- Bataille, N., Laprée-Delage, G., Tauphin, JL. Concentration of leukaemia inhibitory factor (LIF) intrauterine flushing fluid is highly predictive of embryo implantation. Hum Reprod, 2002, 17, p. 213–218.

17. Lessey, BA., Castelbaum, AJ. Sawin, SW., et al. Aberrant integrin expression in the endometrium of women with endometriosis. J Clin Endocrinol Metab, 1994, 79, p. 643–649.

18. Lessey, BA., Yeh, I., Castelbaum, AJ., et al. Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation. Fertil Steril, 1996, 65, p. 477–483.

19. Lessey, BA., Castelbaum, AJ., Sawin, SW., et al. Integrins as markers of uterine receptivity in women with primary unexplained infertility. Fertil Steril, 1995, 12, p. 1393–1398.

20. Lessey, BA., Damjanovich, L., Coutifaris, C., et al. Integrin adhesion molecules in human endometrium: correlation with normal and abnormal menstrual cycles. J Clin Invest, 1992, 90, p. 188–195.

21. Loke, YW., Gardner, L., Burland, K., et al. Laminin in human trophoblast- decidua interaction. Hum Reprod, 1989, 4, p. 457–463.

22. Martel, D., Monier, MN., Roiche, D., et al. Hormonal dependence of pinopode formation at the uterine luminal surface. Hum Reprod, 1991, 6, p. 597–603.

23. Meseguer, M., Apli, JD., Caballero-Campo, P., et al. Human endometrial mucin MUC 1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod, 2001, 64, p. 590–602.

24. Meyer, WR., Castelbaum, AJ., Somkuti, S., et al. Hydrosalpinges adversely affect marker of endometrial reveptivity. Hum Reprod 1997, 12, p. 1393–1398.

25. Psychoyos, A. Hormonal control of ovoimplantation. Vitam Horm, 1973, 31, p. 201–256.

26. Sharkey, AM., Dellow, K., Blayney, M., et al. Stage specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos. Biol Reprod, 1995, 53,p. 974–981.

27. Seshadri, S., Sunkara, SK., Khalaf, Y., et al. Effect of heparin on the outcome of IVF treatment: A systematic review and meta-analysis. Reprod BioMed Online, 2012, 25, p. 572–584.

28. Simon, C., Gimeno, MJ., Mercade, A., et al. Embryonic regulation of integrins β3, α4 and α1 in human endometrial epithelial cells in vitro. J Clin Endocrinol Metab, 1997, 82, p. 2607–2616.

29. Simon, C., Moreno, C., Remohi, J. Cytokines and embryo implantation. J Reprod Immunol, 39, 1998, p. 117–131.

30. Simon, C., Piquette, GN., Frances, A., et al. Localization of interleukin-1 type 1- receptor and interleukin 1 β in human endometrium throughout the menstrual cycle. J Clin Endocrinol Metab, 1993, 77, p. 549–555.

31. Simur, A., Ozdemir, S., Acar, H. Repeated in vitro fertilization failure and its relation with thrombophilia. Gynecol Obstet Invest, 2009, 67, p. 109–112.

32. Qublan, H., Eid, S., Ababneh, H., Amarin, Z. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod, 2006, 21, p. 2694–2698.

33. Qublan, H., Amarin, Z., Dabbas, M., Farraj, AE. Low molecular weight heparin in the treatment of recurrent IVF-ET failure and thrombophilia: a prospective randomized placebo – controlled trial. Hum Fertil, 2008, 11, p. 246–253.