#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Rosemary – its biologically active compounds and their pharmacological effects


Authors: Jana Karlíčková;  Aneta Klížová
Authors‘ workplace: Katedra farmakognozie a farmaceutické botaniky, Farmaceutická fakulta Univerzity Karlovy v Hradci Králové
Published in: Čes. slov. Farm., 2024; 73, 42-46
Category: Medical Plants and Nutraceutics
doi: https://doi.org/10.36290/csf.2024.008

Overview

Rosemary – its biologically active compounds and their pharmacological effects

Rosemary (Rosmarinus officinalis L.) has been used since ancient times for medicinal, cultic, and magic purposes. With the stress and diseases, it is increasingly popular today for many uses in both pharmacy and aromatherapy, as a spice in the kitchen and as a preservative. This plant has many interesting compounds (e.g. rosmarinic and carnosic acid, carnosol), which show a considerable amount of positive pharmacological effects.

Keywords:

rosemary (Rosmarinus officinalis L.), biologically active compounds, pharmacological effects


Sources

1. EMA. 2009. Assessment report on Rosmarinus officinalis L., folium. Committee on Herbal Medicinal Products (HMPC), EMA/HMPC/13633/2009. EMA. 2009. Assessment report on Rosmarinus officinalis L., aetheroleum. Committee on Herbal Medicinal Products (HMPC), EMA/HMPC/235453/2009.

2. Český lékopis 2017. 4. díl, MZ ČR, Grada Publishing a. s. 2017./ Ph. Eur. 2024. Rosmarinus leaf.  European Pharmacopoeia, 11th ed. Strasbourg, France: EDQM, 01/2011:1828. Ph. Eur. 2024. Rosemary oil.  European Pharmacopoeia, 11th ed. Strasbourg, France: EDQM, 01/2008:1846.

3. Drew BT, González-Gallegos JG, Xiang Ch., Kriebel R. Salvia united: The greatest good for the greatest number. Taxon. 2017;66(1):133-145.

4. Kaplan Z, Danihelka J, Chrtek Jjun., Kirschner J, Kubát K, Štech M & Štěpánek J(eds). Klíč ke květeně České republiky. Academia, Praha 2019.

5. Jahodář L. Léčivé rostliny v současné medicíně: (co Mattioli ještě nevěděl). Havlíček Brain Team, Praha 2010.

6. Jellin JM, Gregory P, Batz F, et al.  Natural Medicines Comprehensive Database. Therapeutic Research, Stockton 2000.

7. Jahodář L.  Farmakobotanika – semenné rostliny. Karolinum, Praha 2011.

8. Ribeiro-Santos R, Carvalho-Costa D, Cavaleiro C, et al. A novel insight on an ancient aromatic plant: The rosemary (Rosmarinus officinalis L.). Trends Food Sci Technol. 2015;45(2):355-368.

9. Braun L, Cohen M. Herbs and Natural Supplements, An evidence-based guide. Elsevier, Australia 2015.

10. Roy DN. Terpenoids against human diseases. CRS Press, Boca Raton 2019.

11. Aguilar F, Barlow S, Castle L, et al. Use of rosemary extracts as a food additive – Scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food. EFSA J. 2008;8(7):1-29.

12. Veenstra JP, Johnson JJ. Rosemary (Salvia rosmarinus): Health-promoting benefits and food preservative properties, Int J Nutr. 2021;6(4):1-10.

13. Günther M, Karygianni L, Argyropoulou A, et al. The antimicrobial effect of Rosmarinus officinalis extracts on oral initial adhesion ex vivo. Clin Oral Investig. 2022;26(6):4369-4380.

14. de Oliveira JR, de Jesus D, Figueira LW, et al. Biological activities of Rosmarinus officinalis L. (rosemary) extract as analyzed in microorganisms and cells. Exp Biol Med (Maywood). 2017;242(6):625-634. 

15. Shin HB, Choi MS, Ryu B, et al. Antiviral activity of carnosic acid against respiratory syncytial virus. Virol J. 2013;10:303.

16. Al-Megrin WA, AlSadhan NA, Metwally DM, et al. Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2. Biosci Rep. 2020;40(6):BSR20200992.

17. de Macedo LM, Santos ÉM, Militão L, et al. Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and its topical applications. A review, Plants: 2020;9(5).

18. Moss M, Cook J, Wesnes K, Duckett P. Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults. Int J Neurosci. 2003;113(1):15-38.

19. Nematolahi P, Mehrabani M, Karami-Mohajeri S, Dabaghzadeh F. Effects of Rosmarinus officinalis L. on memory performance, anxiety, depression, and sleep quality in university students: A randomized clinical trial. Complement Ther Clin Pract. 2018;30:24-28.

20. Altinier G, Sosa S, Aquino RP, et al. Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L., J Agric Food Chem. 2007;55(5):1718.

21. Gonçalves C, Fernandes D, Silva I, Mateus V. Potential Anti-Inflammatory Effect of Rosmarinus officinalis in Preclinical In Vivo Models of Inflammation. Molecules. 2022;27(3):609.

22. Tsai TH, Chuang LT, Lien TJ, et al. Rosmarinus officinalis extract suppresses Propionibacterium acnes-induced inflammatory responses. J Med Food. 2013;16(4):324-33. 

23. Rašković A, Milanović I, Pavlović N, et al. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Altern Med. 2014;14:225.

24. Mahady GB, Pendland SL, Stoia A, et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005;19(11):988-91.

25. Allegra A, Tonacci A, Pioggia G, et al. Anticancer Activity of Rosmarinus officinalis L.: Mechanisms of Action and Therapeutic Potentials. Nutrients 2020;12(6):1739.

26. Yan M, Vemu B, Veenstra J, et al. a dietary diterpene from rosemary (Rosmarinus officinalis) activates Nrf2 leading to sestrin 2 induction in colon cells. Integr Mol Med. 2018;5(4):10.

27. Fernández-Ochoa A, Borrás-Linares I, Pérez-Sánchez A, et al. Phenolic compounds in rosemary as potential source of bioactive compounds against colorectal cancer: In situ absorption and metabolism study, J Funct Foods. 2017;33:202-210.

Další literatura k získání u autorky

Labels
Pharmacy Clinical pharmacology

Article was published in

Czech and Slovak Pharmacy

Issue 1

2024 Issue 1

Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#