Obsolete for many years but still in use – consumption of phenobarbital in compounding pharmacies

Czech version

Authors: Miroslav Turjap ¹; Eva Pailová ²; Jan Juřica ^3,4
Authors‘ workplace: Oddělení klinické farmacie, Lékárna Fakultní nemocnice Ostrava ¹; Oddělení přípravy léčivých přípravků, Lékárna Fakultní nemocnice Ostrava ²; Farmakologický ústav, Lékařská fakulta a Ústav farmakologie a toxikologie, Farmaceutická fakulta, Masarykova univerzita Brno ³; Ústavní lékárna, Masarykův onkologický ústav, Brno ⁴
Published in: Čes. slov. Farm., 2024; 73, 8-12
Category: Current Pharmacotherapy
doi: https://doi.org/10.36290/csf.2024.001

Overview

Phenobarbital was synthesized by the German organic chemist Emil Fischer in 1911. It is approved and marketed in the Czech Republic as an antiepileptic in tablet and injection form. Although phenobarbital as a hypnosedative has been outdated for decades, it is still available as a substance and used for the individual compounding of various obsolete mixtures. It is likely that prescribers are unaware of the risks associated with their use. The article presents a brief pharmacological profile of phenobarbital, lists the most often used mixtures, substance consumption and risks associated with its use.

Keywords:

phenobarbital, individual compounding, obsolete mixtures, drug-drug interactions, drug safety.

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